Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies

Peter H Langlois; Adrienne T Hoyt; Philip J Lupo; Christina C Lawson; Martha A Waters; Tania A Desrosiers; Gary M Shaw; Paul A Romitti; Edward J Lammer; National Birth Defects Prevention Study

doi:10.1002/bdra.23045

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Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies

Journal article

Open access

Peer reviewed

Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies

Peter H Langlois, Adrienne T Hoyt, Philip J Lupo, Christina C Lawson, Martha A Waters, Tania A Desrosiers, Gary M Shaw, Paul A Romitti, Edward J Lammer and National Birth Defects Prevention Study

Birth defects research. A Clinical and molecular teratology, Vol.94(9), pp.693-700

09/2012

DOI: 10.1002/bdra.23045

PMCID: PMC5048886

PMID: 22807044

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https://www.ncbi.nlm.nih.gov/pmc/articles/5048886View

Open Access

Abstract

This study evaluated whether there is an association between maternal occupational exposure to polycyclic aromatic hydrocarbons (PAHs) and neural tube defects (NTDs) in offspring. This is the first such study of which the authors are aware. Data were analyzed from 1997 to 2002 deliveries in the National Birth Defects Prevention Study, a large population-based case-control study in the United States. Maternal interviews yielded information on jobs held in the month before through 3 months after conception. Three industrial hygienists blinded to case or control status assessed occupational exposure to PAHs. Crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Of the 520 mothers of children with NTDs, 5.0% were classified as exposed to occupational PAHs, as were 3.5% of the 2989 mothers of controls. The crude OR for PAH exposure was 1.43 (95% CI, 0.92-2.22) for any NTD and 1.71 (95% CI, 1.03-2.83) for spina bifida. Adjusted ORs were smaller in magnitude and not significant. Among women who were normal weight or underweight, the crude OR for spina bifida was 3.13 (95% CI, 1.63-6.03) and adjusted OR was 2.59 (95% CI, 1.32-5.07). Based on estimated cumulative exposure, a statistically significant dose-response trend was observed for spina bifida; however, it was attenuated and no longer significant after adjustment. Maternal occupational exposure to PAHs may be associated with increased risk of spina bifida in offspring among women who are normal weight or underweight. Other comparisons between PAHs and NTDs were consistent with no association.

Pregnancy

United States - epidemiology

Body Weight

Polycyclic Aromatic Hydrocarbons - toxicity

Maternal-Fetal Exchange

Occupational Exposure - adverse effects

Humans

Neural Tube Defects - epidemiology

Logistic Models

Case-Control Studies

Neural Tube - drug effects

Neural Tube - pathology

Spinal Dysraphism - epidemiology

Adolescent

Maternal Exposure - adverse effects

Adult

Female

Odds Ratio

Infant, Newborn

Details

Title: Subtitle: Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies
Creators: Peter H Langlois - Texas Center for Birth Defects Research and Prevention, Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas 78714-9347, USA. peter.langlois@dshs.state.tx.us
Adrienne T Hoyt
Philip J Lupo
Christina C Lawson
Martha A Waters
Tania A Desrosiers
Gary M Shaw
Paul A Romitti
Edward J Lammer
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.94(9), pp.693-700
DOI: 10.1002/bdra.23045
PMID: 22807044
PMCID: PMC5048886
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U01 DD000494 / NCBDD CDC HHS L40 DE023736 / NIDCR NIH HHS P30 ES023512 / NIEHS NIH HHS U01DD000494 / NCBDD CDC HHS L40 RR033250 / NCRR NIH HHS 200-2000-08018 / PHS HHS
Language: English
Date published: 09/2012
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995050302771

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