Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Philip J Lupo; Elaine Symanski; Peter H Langlois; Christina C Lawson; Sadia Malik; Suzanne M Gilboa; Laura J Lee; A J Agopian; Tania A Desrosiers; Martha A Waters; Paul A Romitti; Adolfo Correa; Gary M Shaw; Laura E Mitchell; National Birth Defects Prevention Study

doi:10.1002/bdra.23071

Back

Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Journal article

Peer reviewed

Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study

Philip J Lupo, Elaine Symanski, Peter H Langlois, Christina C Lawson, Sadia Malik, Suzanne M Gilboa, Laura J Lee, A J Agopian, Tania A Desrosiers, Martha A Waters, …

Birth defects research. A Clinical and molecular teratology, Vol.94(11), pp.875-881

11/2012

DOI: 10.1002/bdra.23071

PMCID: PMC4552186

PMID: 22945317

View Online

Abstract

There is evidence in experimental model systems that exposure to polycyclic aromatic hydrocarbons (PAHs) results in congenital heart defects (CHDs); however, to our knowledge, this relationship has not been examined in humans. Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring. The prevalence of occupational PAH exposure was 4.0% in CHD case mothers (76/1907) and 3.6% in control mothers (104/2853). After adjusting for maternal age, race or ethnicity, education, smoking, folic acid supplementation, and study center, exposure was not associated with conotruncal defects (adjusted odds ratio [AOR], 0.98; 95% confidence interval [CI], 0.58-1.67), septal defects (AOR, 1.28; 95% CI, 0.86-1.90), or with any isolated CHD subtype. Our findings do not support an association between potential maternal occupational exposure to PAHs and various CHDs in a large, population-based study. For CHD phenotypic subtypes in which modest nonsignificant associations were observed, future investigations could be improved by studying populations with a higher prevalence of PAH exposure and by incorporating information on maternal and fetal genotypes related to PAH metabolism. Birth Defects Research (Part A), 2012.

Pregnancy

United States - epidemiology

Prevalence

Polycyclic Aromatic Hydrocarbons - toxicity

Heart Defects, Congenital - etiology

Occupational Exposure - adverse effects

Prenatal Exposure Delayed Effects - epidemiology

Humans

Risk Factors

Prenatal Exposure Delayed Effects - prevention & control

Infant

Logistic Models

Male

Prenatal Exposure Delayed Effects - etiology

Case-Control Studies

Health Surveys

Heart Defects, Congenital - prevention & control

Heart Defects, Congenital - epidemiology

Maternal Exposure - adverse effects

Adult

Female

Odds Ratio

Details

Title: Subtitle: Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study
Creators: Philip J Lupo - Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX 77030, USA. Philip.J.Lupo@uth.tmc.edu
Elaine Symanski
Peter H Langlois
Christina C Lawson
Sadia Malik
Suzanne M Gilboa
Laura J Lee
A J Agopian
Tania A Desrosiers
Martha A Waters
Paul A Romitti
Adolfo Correa
Gary M Shaw
Laura E Mitchell
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.94(11), pp.875-881
DOI: 10.1002/bdra.23071
PMID: 22945317
PMCID: PMC4552186
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U01 DD000494 / NCBDD CDC HHS PA 02081 / PHS HHS FOA DD09-001 / NCBDD CDC HHS U01DD000494 / NCBDD CDC HHS CC999999 / Intramural CDC HHS PA 96043 / PHS HHS
Language: English
Date published: 11/2012
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995052802771

Metrics

22 Record Views

39 Times Cited - Web of Science

See more details