Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study

Jacqueline L O'Brien; Peter H Langlois; Christina C Lawson; Angela Scheuerle; Carissa M Rocheleau; Martha A Waters; Elaine Symanski; Paul A Romitti; A J Agopian; Philip J Lupo; National Birth Defects Prevention Study

doi:10.1002/bdra.23389

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Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study

Journal article

Open access

Peer reviewed

Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study

Jacqueline L O'Brien, Peter H Langlois, Christina C Lawson, Angela Scheuerle, Carissa M Rocheleau, Martha A Waters, Elaine Symanski, Paul A Romitti, A J Agopian, Philip J Lupo, …

Birth defects research. A Clinical and molecular teratology, Vol.106(1), pp.55-60

01/2016

DOI: 10.1002/bdra.23389

PMCID: PMC4668225

PMID: 26033890

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Abstract

Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR] = 1.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR = 1.76, 95% CI, 0.82-3.75), but was not significant. Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes.

Pregnancy

Craniosynostoses - epidemiology

United States - epidemiology

Prevalence

Occupational Exposure - adverse effects

Humans

Male

Case-Control Studies

Craniosynostoses - etiology

Polycyclic Aromatic Hydrocarbons - adverse effects

Maternal Exposure - adverse effects

Adult

Female

Surveys and Questionnaires

Retrospective Studies

Odds Ratio

Infant, Newborn

Details

Title: Subtitle: Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study
Creators: Jacqueline L O'Brien - Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
Peter H Langlois - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas
Christina C Lawson - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
Angela Scheuerle - Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas
Carissa M Rocheleau - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
Martha A Waters - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio
Elaine Symanski - Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas
Paul A Romitti - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City
A J Agopian - Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas
Philip J Lupo - Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.106(1), pp.55-60
DOI: 10.1002/bdra.23389
PMID: 26033890
PMCID: PMC4668225
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: United States
Grant note: U01 DD000494 / NCBDD CDC HHS P30 ES005605 / NIEHS NIH HHS P30 ES023512 / NIEHS NIH HHS R03DE021739 / NIDCR NIH HHS U01DD000494 / NCBDD CDC HHS CC999999 / Intramural CDC HHS DYT1 / Intramural CDC HHS L40 DE023736 / NIDCR NIH HHS R03 DE021739 / NIDCR NIH HHS U01 DD001035 / NCBDD CDC HHS 200-2000-08018 / PHS HHS
Language: English
Date published: 01/2016
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995062902771

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