Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study

Carissa M Rocheleau; Stephen J Bertke; Christina C Lawson; Paul A Romitti; Wayne T Sanderson; Sadia Malik; Philip J Lupo; Tania A Desrosiers; Erin Bell; Charlotte Druschel; Adolfo Correa; Jennita Reefhuis; National Birth Defects Prevention Study

doi:10.1002/bdra.23351

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Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study

Journal article

Peer reviewed

Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study

Carissa M Rocheleau, Stephen J Bertke, Christina C Lawson, Paul A Romitti, Wayne T Sanderson, Sadia Malik, Philip J Lupo, Tania A Desrosiers, Erin Bell, Charlotte Druschel, …

Birth defects research. A Clinical and molecular teratology, Vol.103(10), pp.823-833

10/2015

DOI: 10.1002/bdra.23351

PMCID: PMC4607631

PMID: 26033688

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Abstract

Congenital heart defects (CHDs) are common birth defects, affecting approximately 1% of live births. Pesticide exposure has been suggested as an etiologic factor for CHDs, but previous results were inconsistent. We examined maternal occupational exposure to fungicides, insecticides, and herbicides for 3328 infants with CHDs and 2988 unaffected control infants of employed mothers using data for 1997 through 2002 births from the National Birth Defects Prevention Study, a population-based multisite case-control study. Potential pesticide exposure from 1 month before conception through the first trimester of pregnancy was assigned by an expert-guided task-exposure matrix and job history details self-reported by mothers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression. Maternal occupational exposure to pesticides was not associated with CHDs overall. In examining specific CHD subtypes compared with controls, some novel associations were observed with higher estimated pesticide exposure: insecticides only and secundum atrial septal defect (OR = 1.8; 95% CI, 1.3-2.7, 40 exposed cases); both insecticides and herbicides and hypoplastic left heart syndrome (OR = 5.1; 95% CI, 1.7-15.3, 4 exposed cases), as well as pulmonary valve stenosis (OR = 3.6; 95% CI, 1.3-10.1, 5 exposed cases); and insecticides, herbicides, and fungicides and tetralogy of Fallot (TOF) (OR = 2.2; 95% CI, 1.2-4.0, 13 exposed cases). Broad pesticide exposure categories were not associated with CHDs overall, but examining specific CHD subtypes revealed some increased odds ratios. These results highlight the importance of examining specific CHDs separately. Because of multiple comparisons, additional work is needed to verify these associations.

Pregnancy

United States

Heart Defects, Congenital - chemically induced

Occupational Exposure - adverse effects

Humans

Risk Factors

Heart Defects, Congenital - epidemiology

Maternal Exposure - adverse effects

Adult

Female

Pesticides - adverse effects

Retrospective Studies

Details

Title: Subtitle: Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study
Creators: Carissa M Rocheleau - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio
Stephen J Bertke - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio
Christina C Lawson - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio
Paul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa
Wayne T Sanderson - Department of Epidemiology, University of Kentucky, Lexington, Kentucky
Sadia Malik - University of Arkansas for Medical Sciences, Little Rock, Arkansas
Philip J Lupo - Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas
Tania A Desrosiers - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina
Erin Bell - Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, Rensselaer, New York
Charlotte Druschel - Center for Environmental Health, New York State Department of Health, Albany, New York
Adolfo Correa - Departments of Medicine and Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi
Jennita Reefhuis - Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.103(10), pp.823-833
DOI: 10.1002/bdra.23351
PMID: 26033688
PMCID: PMC4607631
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U01 DD000492 / NCBDD CDC HHS U01/DD000492 / NCBDD CDC HHS IKE9 / Intramural CDC HHS P30 ES005605 / NIEHS NIH HHS R24 HD044943 / NICHD NIH HHS U01/DD001035 / NCBDD CDC HHS U01 DD001035 / NCBDD CDC HHS 200-2000-08018 / PHS HHS
Language: English
Date published: 10/2015
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983996188402771

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