Maternal periconceptional alcohol consumption and risk of orofacial clefts

Paul A Romitti; Lixian Sun; Margaret A Honein; Jennita Reefhuis; Adolfo Correa; Sonja A Rasmussen; the National Birth Defects Prevention Study

doi:10.1093/aje/kwm146

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Maternal periconceptional alcohol consumption and risk of orofacial clefts

Journal article

Open access

Peer reviewed

Maternal periconceptional alcohol consumption and risk of orofacial clefts

Paul A Romitti, Lixian Sun, Margaret A Honein, Jennita Reefhuis, Adolfo Correa, Sonja A Rasmussen and the National Birth Defects Prevention Study

American journal of epidemiology, Vol.166(7), pp.775-785

10/01/2007

DOI: 10.1093/aje/kwm146

PMID: 17609516

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Abstract

Using data from the National Birth Defects Prevention Study, the authors investigated the association between maternal reports of periconceptional alcohol consumption and clefting. Cases with a cleft lip, cleft palate, or both and unaffected controls delivered from 1997 through 2002 were ascertained. Interview reports of alcohol consumption were obtained from 1,749 (75.1%) case and 4,094 (68.2%) control mothers. Adjusted odds ratios and 95% confidence intervals were calculated to assess associations. Compared with odds ratios for mothers with no reported consumption, those for mothers who consumed alcohol tended to be near to (cleft lip, cleft lip with cleft palate) or to exceed (cleft palate) unity. The odds ratios associated with binge drinking were elevated but did not demonstrate significantly increased risk for any phenotype; however, the odds ratios differed by the type of alcohol consumed, particularly for cleft palate (distilled spirits > wine > beer). These odds ratios were further increased among mothers with no reported folic acid intake. Although these findings suggest that the association between alcohol consumption and clefting might be most influenced by the type of beverage consumed and folic acid intake, they are preliminary and might reflect chance associations. Such findings need exploration in additional, large studies.

United States - epidemiology

Cleft Lip - chemically induced

Humans

Cleft Palate - genetics

Folic Acid - administration & dosage

Maternal Exposure

Case-Control Studies

Congenital Abnormalities

Time Factors

Risk-Taking

Adult

Female

Nutritional Status

Odds Ratio

Cleft Palate - chemically induced

Risk Assessment

Cleft Lip - epidemiology

Risk Factors

Alcohol Drinking - adverse effects

Centers for Disease Control and Prevention (U.S.)

Pregnancy

Cleft Lip - genetics

Phenotype

Adolescent

Cleft Palate - epidemiology

Prenatal Exposure Delayed Effects - chemically induced

Details

Title: Subtitle: Maternal periconceptional alcohol consumption and risk of orofacial clefts
Creators: Paul A Romitti - Department of Epidemiology, The University of Iowa, Iowa City, IA 52242, USA
Lixian Sun
Margaret A Honein
Jennita Reefhuis
Adolfo Correa
Sonja A Rasmussen
the National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.166(7), pp.775-785
Publisher: United States
DOI: 10.1093/aje/kwm146
PMID: 17609516
ISSN: 0002-9262
eISSN: 1476-6256
Grant note: U50-CCU 713238 / PHS HHS
Language: English
Date published: 10/01/2007
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995135002771

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