Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +/- tracheo-esophageal fistula

Donna L Wong-Gibbons; Paul A Romitti; Lixian Sun; Cynthia A Moore; Jennita Reefhuis; Erin M Bell; Andrew F Olshan; Natl Birth Defects Prevention

doi:10.1002/bdra.20529

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Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +/- tracheo-esophageal fistula

Journal article

Open access

Peer reviewed

Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +/- tracheo-esophageal fistula

Donna L Wong-Gibbons, Paul A Romitti, Lixian Sun, Cynthia A Moore, Jennita Reefhuis, Erin M Bell, Andrew F Olshan and Natl Birth Defects Prevention

Birth defects research. A Clinical and molecular teratology, Vol.82(11), pp.776-784

11/2008

DOI: 10.1002/bdra.20529

PMCID: PMC6042846

PMID: 18985694

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https://www.ncbi.nlm.nih.gov/pmc/articles/6042846View

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Abstract

Esophageal atresia (EA) is a moderately frequent birth defect that often occurs with tracheo-esophageal fistula (TEF). Etiologic studies for EA+/-TEF have produced inconsistent results. This study used data from the National Birth Defects Prevention Study (NBDPS) to examine the association between maternal periconceptional exposure to cigarette smoking and alcohol and EA+/-TEF. Cases of EA+/-TEF and unaffected controls with an estimated date of delivery from October 1997 through December 2003 were identified, and telephone interview reports for smoking and alcohol exposure were obtained from birth mothers of 334 cases and 4,967 controls. Odds ratios (OR)s and 95% confidence intervals (CI)s, adjusted for several covariates, were calculated to assess associations. ORs were near unity for all EA+/-TEF cases combined and any periconceptional exposure to cigarette smoking (OR = 1.1; CI = 0.8,1.6) or alcohol (OR = 1.2; CI = 0.8,1.8). For cigarette smoking, some elevated ORs were found but varied by type of smoking exposure. No consistent patterns were identified for number of cigarettes smoked per day. For alcohol, ORs were weak to moderately elevated with increasing number of drinks consumed and for binge drinkers compared to non-binge drinkers. ORs were further elevated among mothers who reported active+passive exposure to cigarette smoking and alcohol (OR = 2.5; CI = 1.1,5.6). For both exposures, ORs were higher for cases with additional major defects compared to isolated cases. These results, based on one of the largest published samples of EA+/-TEF cases, suggest a role for these exposures in the etiology of EA+/-TEF, although further study is needed to replicate the observed associations.

Pregnancy

Smoking - adverse effects

Tracheoesophageal Fistula - epidemiology

Esophageal Atresia - epidemiology

Humans

Risk Factors

Prenatal Exposure Delayed Effects - etiology

Alcohol Drinking - adverse effects

Maternal Exposure

Case-Control Studies

Esophageal Atresia - etiology

Young Adult

Adult

Female

Tracheoesophageal Fistula - etiology

Details

Title: Subtitle: Maternal periconceptional exposure to cigarette smoking and alcohol and esophageal atresia +/- tracheo-esophageal fistula
Creators: Donna L Wong-Gibbons - Department of Epidemiology, University of Iowa, Iowa City, Iowa 52242, USA
Paul A Romitti
Lixian Sun
Cynthia A Moore
Jennita Reefhuis
Erin M Bell
Andrew F Olshan
Natl Birth Defects Prevention
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.82(11), pp.776-784
DOI: 10.1002/bdra.20529
PMID: 18985694
PMCID: PMC6042846
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U50/CCU 713238 / PHS HHS U50 DD713238 / NCBDD CDC HHS
Language: English
Date published: 11/2008
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995130602771

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