Journal article
Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects
International journal of hygiene and environmental health, Vol.217(2-3), pp.248-254
03/2014
DOI: 10.1016/j.ijheh.2013.06.003
PMCID: PMC4524544
PMID: 23871272
Abstract
This population-based U.S. study investigated the association between major musculoskeletal malformations and periconceptional maternal occupational pesticide exposure for a wide range of occupations. We conducted a multi-site case–control analysis using data from the National Birth Defects Prevention Study among employed women with due dates from October 1, 1997 through December 31, 2002. Cases included 871 live-born, stillborn, or electively terminated fetuses with isolated craniosynostosis, gastroschisis, diaphragmatic hernia, or transverse limb deficiencies. Controls included 2857 live-born infants without major malformations. Using self-reported maternal occupational information, an industrial hygienist used a job-exposure matrix and expert opinion to evaluate the potential for exposure to insecticides, herbicides or fungicides for each job held during one month pre-conception through three months post-conception. Exposures analyzed included any exposure (yes/no) to pesticides, to insecticides only, to both insecticides and herbicides (I+H) and to insecticides, herbicides and fungicides (I+H+F). We used logistic regression to evaluate the association between exposures and defects, controlling for infant and maternal risk factors. Occupational exposure to I+H+F was associated with gastroschisis among infants of women aged 20 years or older (adjusted odds ratio [aOR]=1.88; 95% confidence interval [CI]: 1.16–3.05), but not for women under age 20 (aOR=0.48; 95% CI: 0.20–1.16). We found no significant associations for the other defects. Additional research is needed to validate these findings in a separate population.
Details
- Title: Subtitle
- Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects
- Creators
- Christine Kielb - NYS Department of Health, Center for Environmental Health, Troy, NY, United StatesShao Lin - NYS Department of Health, Center for Environmental Health, Troy, NY, United StatesMichele Herdt-Losavio - NYS Department of Health, Center for Environmental Health, Troy, NY, United StatesErin Bell - University at Albany School of Public Health, Rensselaer, NY, United StatesBonnie Chapman - Upstate Medical University, SUNY, Syracuse, NY, United StatesCarissa M Rocheleau - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), Cincinnati, OH, United StatesChristina Lawson - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), Cincinnati, OH, United StatesMartha Waters - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention (CDC), Cincinnati, OH, United StatesPatricia Stewart - Stewart Exposure Assessments, LLC, Arlington, VA, United StatesRichard S Olney - National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United StatesPaul A Romitti - University of Iowa School of Public Health, Iowa City, IA, United StatesYanyan Cao - University of Iowa School of Public Health, Iowa City, IA, United StatesCharlotte Druschel - NYS Department of Health, Center for Environmental Health, Troy, NY, United Statesthe National Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- International journal of hygiene and environmental health, Vol.217(2-3), pp.248-254
- DOI
- 10.1016/j.ijheh.2013.06.003
- PMID
- 23871272
- PMCID
- PMC4524544
- NLM abbreviation
- Int J Hyg Environ Health
- ISSN
- 1438-4639
- eISSN
- 1618-131X
- Publisher
- Elsevier GmbH
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983995137002771
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