Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001

Ridgely Fisk Green; Richard S Olney; Jennita Reefhuis; Lorenzo D Botto; Paul A Romitti; National Birth Defects Prevention Study

doi:10.1097/GIM.0b013e31815f1def

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Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001

Journal article

Open access

Peer reviewed

Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001

Ridgely Fisk Green, Richard S Olney, Jennita Reefhuis, Lorenzo D Botto, Paul A Romitti and National Birth Defects Prevention Study

Genetics in medicine, Vol.10(1), pp.37-45

01/2008

DOI: 10.1097/GIM.0b013e31815f1def

PMID: 18197055

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Abstract

To assess usefulness of family history information obtained in pediatric practice, we evaluated maternally reported family history data. We analyzed family history responses from the National Birth Defects Prevention Study using interview data from mothers of children with birth defects (n = 9,331) and of unaffected liveborn children (n = 3,390) with 1997-2001 estimated delivery dates. We examined the effects of demographic factors, case-control status, and type of defect on birth defect family history reports. Interview information was compared with occurrence of prenatal testing. Among case mothers, 1,577 (17%) reported a first- or second-degree relative with a birth defect, compared with 327 (10%) control mothers (odds ratio = 1.91, 95% confidence interval = 1.68-2.16). Reports of affected relatives were also more frequent among mothers who were non-Hispanic white, were 25 years or older, had more than 12 years of education, had an annual household income greater than $20,000, were born in the United States, and completed an English-language interview. Reporting a family history of birth defects might be influenced by maternal demographic factors, which should be considered in developing pediatric family history tools.

Medical History Taking

Congenital Abnormalities - prevention & control

United States

Humans

Prenatal Diagnosis

Infant

Mothers

Case-Control Studies

Pregnancy

Congenital Abnormalities - ethnology

Adult

Female

Retrospective Studies

Details

Title: Subtitle: Maternal reports of family history from the National Birth Defects Prevention Study, 1997-2001
Creators: Ridgely Fisk Green - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. grf1@cdc.gov
Richard S Olney
Jennita Reefhuis
Lorenzo D Botto
Paul A Romitti
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Genetics in medicine, Vol.10(1), pp.37-45
Publisher: United States
DOI: 10.1097/GIM.0b013e31815f1def
PMID: 18197055
ISSN: 1098-3600
eISSN: 1530-0366
Language: English
Date published: 01/2008
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995179702771

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