Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study

Marilyn L Browne; Sonja A Rasmussen; Adrienne T Hoyt; D Kim Waller; Charlotte M Druschel; Alissa R Caton; Mark A Canfield; Angela E Lin; Suzan L Carmichael; Paul A Romitti; National Birth Defects Prevention Study

doi:10.1002/bdra.20573

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Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study

Journal article

Open access

Peer reviewed

Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study

Marilyn L Browne, Sonja A Rasmussen, Adrienne T Hoyt, D Kim Waller, Charlotte M Druschel, Alissa R Caton, Mark A Canfield, Angela E Lin, Suzan L Carmichael, Paul A Romitti, …

Birth defects research. A Clinical and molecular teratology, Vol.85(7), pp.621-628

07/2009

DOI: 10.1002/bdra.20573

PMCID: PMC6034621

PMID: 19215015

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https://www.ncbi.nlm.nih.gov/pmc/articles/6034621View

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Abstract

Although thyroid disorders are present in approximately 3% of pregnant women, little is known about the association between maternal thyroid disease and birth defects. We assessed the association between maternal thyroid disease, thyroid medication use, and 38 types of birth defects among 14,067 cases and 5875 controls in the National Birth Defects Prevention Study, a multisite, population-based, case-control study. Infants in this study were born between October 1997 and December 2004. Information on exposures including maternal diseases and use of medications was collected by telephone interview. We found statistically significant associations between maternal thyroid disease and left ventricular outflow tract obstruction heart defects (1.5; 95% CI, 1.0-2.3), hydrocephaly (2.9; 95% CI, 1.6-5.2), hypospadias (1.6; 95% CI, 1.0-2.5), and isolated anorectal atresia (2.4; 95% CI, 1.2-4.6). Estimates for the association between periconceptional use of thyroxine and specific types of birth defects were similar to estimates for any thyroid disease. Given that antithyroid medication use was rare, we could not adequately assess risks for their use for most case groups. Our results are consistent with the positive associations between maternal thyroid disease or thyroid medication use and both hydrocephaly and hypospadias observed in some previous studies. New associations with left ventricular outflow tract obstruction heart defects and anorectal atresia may be chance findings.

Pregnancy

Congenital Abnormalities - epidemiology

Prenatal Exposure Delayed Effects

Congenital Abnormalities - prevention & control

Thyroid Diseases - drug therapy

Humans

Antithyroid Agents - therapeutic use

Maternal Exposure

Case-Control Studies

Adolescent

Abnormalities, Multiple - epidemiology

Adult

Female

Thyroid Diseases - complications

Pregnancy Complications - prevention & control

Child

Pregnancy Complications - epidemiology

Details

Title: Subtitle: Maternal thyroid disease, thyroid medication use, and selected birth defects in the National Birth Defects Prevention Study
Creators: Marilyn L Browne - Congenital Malformations Registry, New York State Department of Health, Troy, New York, USA. mlb10@health.state.ny.us
Sonja A Rasmussen
Adrienne T Hoyt
D Kim Waller
Charlotte M Druschel
Alissa R Caton
Mark A Canfield
Angela E Lin
Suzan L Carmichael
Paul A Romitti
National Birth Defects Prevention Study
Resource Type: Journal article
Publication Details: Birth defects research. A Clinical and molecular teratology, Vol.85(7), pp.621-628
DOI: 10.1002/bdra.20573
PMID: 19215015
PMCID: PMC6034621
NLM abbreviation: Birth Defects Res A Clin Mol Teratol
ISSN: 1542-0752
eISSN: 1542-0760
Publisher: Wiley; United States
Grant note: U50 DD223184 / NCBDD CDC HHS U50 DD713238 / NCBDD CDC HHS U50/CCU223184 / PHS HHS
Language: English
Date published: 07/2009
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9983995131602771

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