Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir

Kathryn Phillip; Nisha Nair; Kamalika Samanta; Jose F Azevedo; Grant D Brown; Christine A Petersen; Maria Gomes-Solecki

doi:10.1016/j.vaccine.2021.06.025

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Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir

Journal article

Open access

Peer reviewed

Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir

Kathryn Phillip, Nisha Nair, Kamalika Samanta, Jose F Azevedo, Grant D Brown, Christine A Petersen and Maria Gomes-Solecki

Vaccine, Vol.39(31), pp.4320-4327

07/13/2021

DOI: 10.1016/j.vaccine.2021.06.025

PMCID: PMC8495753

PMID: 34172332

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Abstract

•Female mice vaccinated orally with E. coli expressing OspA transferred OspA-specific IgG to pups.•Antibody was transferred via mother’s milk and colostrum.•Serum from pups born to immunized mothers neutralized B. burgdorferi spirochetes in vitro. Lyme Disease presents unique challenges for public health. Transfer of protective antibodies between mothers and offspring should occur after vaccination of mice. We present new evidence for maternal transfer of oral vaccine induced neutralizing anti-OspA IgG antibodies to mouse pups mainly through ingestion of colostrum. We found a strong statistical correlation of antibody transfer between mothers that produced the most robust IgG response to OspA and their respective pups. OspA-specific antibody was detected as early as 24 h after birth and protective levels of antibodies lasted until ~5 weeks of age in the majority of pups but persisted in some mice until 9 weeks. This was further supported by detection of neutralizing antibodies in serum of all pups at 2–3 weeks after birth and in some offspring adult mice at 9 weeks of age. A clear association was found between robust antibody responses in mothers and the length of time antibody persisted in the respective pups using a novel longitudinal Bayesian model. These factors are likely to impact the enzootic cycle of B. burgdorferi if reservoir targeted OspA-based vaccination interventions are implemented.

Bayesian modelling

Borrelia burgdorferi

Lyme disease

Maternal-transfer

Oral vaccination

OspA

Details

Title: Subtitle: Maternal transfer of neutralizing antibodies to B. burgdorferi OspA after oral vaccination of the rodent reservoir
Creators: Kathryn Phillip - University of Tennessee Health Science Center
Nisha Nair - University of Tennessee Health Science Center
Kamalika Samanta - University of Tennessee Health Science Center
Jose F Azevedo - University of Tennessee Health Science Center
Grant D Brown - University of Iowa
Christine A Petersen - University of Iowa
Maria Gomes-Solecki - University of Tennessee Health Science Center
Resource Type: Journal article
Publication Details: Vaccine, Vol.39(31), pp.4320-4327
DOI: 10.1016/j.vaccine.2021.06.025
PMID: 34172332
PMCID: PMC8495753
NLM abbreviation: Vaccine
ISSN: 0264-410X
eISSN: 1873-2518
Publisher: Elsevier Ltd
Language: English
Date published: 07/13/2021
Academic Unit: Epidemiology; Biostatistics; Internal Medicine
Record Identifier: 9984186764302771

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