Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress

Rachel Schroeder; Lynn Nguyen; Andrew A Pieper; Hanna E Stevens

doi:10.1016/j.bbr.2021.113558

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Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress

Journal article

Peer reviewed

Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress

Rachel Schroeder, Lynn Nguyen, Andrew A Pieper and Hanna E Stevens

Behavioural brain research, Vol.416, pp.113558-113558

01/07/2022

DOI: 10.1016/j.bbr.2021.113558

PMCID: PMC8573727

PMID: 34453970

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https://www.ncbi.nlm.nih.gov/pmc/articles/8573727View

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Abstract

Chronic stress during pregnancy harms both the mother and developing child, and there is an urgent unmet need to understand this process in order to develop protective treatments. Here, we report that chronic gestational stress (CGS) causes aberrant maternal care behavior in the form of increased licking and grooming, decreased nursing, and increased time spent nest building. Treatment of CGS-exposed dams with the NAD+-stabilizing agent P7C3-A20 during pregnancy and postpartum, however, preserved normal maternal care behavior. CGS also caused abnormally low weight gain during gestation and postpartum, which was partially ameliorated by maternal treatment with P7C3-A20. Dams also displayed hyperactive locomotion after CGS, which was not affected by P7C3-A20. Although dams did not display a classic depressive-like phenotype after CGS, some changes in anxiety- and depressive-like behaviors were observed. Our results highlight the need for further characterization of the effects of chronic gestational stress on maternal care behavior and provide clues to possible protective mechanisms.

Chronic stress

Drug development

Maternal care

Perinatal behavior

Prenatal stress

Details

Title: Subtitle: Maternal treatment with P7C3-A20 protects from impaired maternal care after chronic gestational stress
Creators: Rachel Schroeder - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
Lynn Nguyen - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
Andrew A Pieper - Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA
Hanna E Stevens - Department of Psychiatry, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Behavioural brain research, Vol.416, pp.113558-113558
DOI: 10.1016/j.bbr.2021.113558
PMID: 34453970
PMCID: PMC8573727
NLM abbreviation: Behav Brain Res
ISSN: 0166-4328
eISSN: 1872-7549
Publisher: Elsevier B.V
Language: English
Date published: 01/07/2022
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984125621602771

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