Journal article
Maternal treatment with opioid analgesics and risk for birth defects
American journal of obstetrics and gynecology, Vol.204(4), pp.314.e1-314.e11
2011
DOI: 10.1016/j.ajog.2010.12.039
PMID: 21345403
Abstract
We examined whether maternal opioid treatment between 1 month before pregnancy and the first trimester was associated with birth defects.
The National Birth Defects Prevention Study (1997 through 2005) is an ongoing population-based case-control study. We estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIS) for birth defects categories with at least 200 case infants or at least 4 exposed case infants.
Therapeutic opioid use was reported by 2.6% of 17,449 case mothers and 2.0% of 6701 control mothers. Treatment was statistically significantly associated with conoventricular septal defects (OR, 2.7; 95% CI, 1.1–6.3), atrioventricular septal defects (OR, 2.0; 95% CI, 1.2–3.6), hypoplastic left heart syndrome (OR, 2.4; 95% CI, 1.4–4.1), spina bifida (OR, 2.0; 95% CI, 1.3–3.2), or gastroschisis (OR, 1.8; 95% CI, 1.1–2.9) in infants.
Consistent with some previous investigations, our study shows an association between early pregnancy maternal opioid analgesic treatment and certain birth defects. This information should be considered by women and their physicians who are making treatment decisions during pregnancy.
Details
- Title: Subtitle
- Maternal treatment with opioid analgesics and risk for birth defects
- Creators
- Cheryl S Broussard - Epidemic Intelligence Service, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, GASonja A Rasmussen - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAJennita Reefhuis - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAJan M Friedman - Department of Medical Genetics, University of British Columbia, and the Child and Family Research Institute, Vancouver, British Columbia, CanadaMichael W Jann - Department of Pharmacy Practice, Mercer University, Atlanta, GATiffany Riehle-Colarusso - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GAMargaret A Honein - Division of Birth Defects and Developmental Disabilities, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GANational Birth Defects Prevention Study
- Contributors
- Paul Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- American journal of obstetrics and gynecology, Vol.204(4), pp.314.e1-314.e11
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajog.2010.12.039
- PMID
- 21345403
- ISSN
- 0002-9378
- eISSN
- 1097-6868
- Grant note
- Centers for Disease Control and Prevention
- Language
- English
- Date published
- 2011
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984213373102771
Metrics
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