Journal article
Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies
International journal of epidemiology, Vol.46(1), pp.190-199
02/01/2017
DOI: 10.1093/ije/dyw035
PMCID: PMC5837498
PMID: 27215617
Abstract
Evidence on association of maternal pre-pregnancy weight with risk of orofacial clefts is inconsistent.
Six large case-control studies of orofacial clefts from Northern Europe and the USA were included in analyses pooling individual-level data. Cases included 4943 mothers of children with orofacial clefts (cleft lip only: 1135, cleft palate with cleft lip: 2081, cleft palate only: 1727) and controls included 10 592 mothers of unaffected children. Association of orofacial cleft risk with pre-pregnancy maternal weight classified by level of body mass index (BMI, kg/m 2 ) was evaluated using logistic regression adjusting for multiple covariates.
Cleft palate, both alone and with cleft lip (CP+/-CL), was associated with maternal class II+ pre-pregnancy obesity (≥ 35)compared with normal weight [adjusted odds ratio (aOR) = 1.36; 95% confidence interval (CI) = 1.16, 1.58]. CP+/-CL was marginally associated with maternal underweight (aOR = 1.16; 95% CI = 0.98, 1.36). Cleft lip alone was not associated with BMI.
In this largest population-based study to date, we found an increased risk of cleft palate, with or without cleft lip, in class II+ obese mothers compared with normal-weight mothers; underweight mothers may also have an increased risk, but this requires further study. These results also suggest that extremes of weight may have a specific effect on palatal development.
Details
- Title: Subtitle
- Maternal underweight and obesity and risk of orofacial clefts in a large international consortium of population-based studies
- Creators
- Hebah Kutbi - Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, USAGeorge L Wehby - Department of Health Management and PolicyLina M Moreno Uribe - Department of OrthodonticsPaul A Romitti - Department of Epidemiology, University of Iowa, Iowa City, IA, USASuzan Carmichael - Department of Pediatrics, Stanford University, Palo Alto, CA, USAGary M Shaw - Department of Pediatrics, Stanford University, Palo Alto, CA, USAAndrew F Olshan - Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USALisa DeRoo - Department of Public Health and Primary Health Care, University of Bergen, Bergen, NorwaySonja A Rasmussen - Centres for Disease Control and Prevention, Atlanta, GA, USAJeffrey C Murray - Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City, IA, USAAllen Wilcox - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USARolv T Lie - Department of Public Health and Primary Health Care, University of Bergen, Bergen, NorwayRonald G Munger - Department of Nutrition, Dietetics, and Food Sciences, Utah State University, Logan, UT, USA
- Resource Type
- Journal article
- Publication Details
- International journal of epidemiology, Vol.46(1), pp.190-199
- DOI
- 10.1093/ije/dyw035
- PMID
- 27215617
- PMCID
- PMC5837498
- NLM abbreviation
- Int J Epidemiol
- ISSN
- 1464-3685
- eISSN
- 1464-3685
- Publisher
- England
- Grant note
- U01 DD000492 / NCBDD CDC HHS P30 ES005605 / NIEHS NIH HHS P2C HD050924 / NICHD NIH HHS R01 DE020895 / NIDCR NIH HHS F32 DE005700 / NIDCR NIH HHS R01 DE008559 / NIDCR NIH HHS R01 HD039061 / NICHD NIH HHS ZIA ES049027 / NIEHS NIH HHS U01 DD000698 / NCBDD CDC HHS U01 DD001035 / NCBDD CDC HHS
- Language
- English
- Date published
- 02/01/2017
- Academic Unit
- Preventive and Community Dentistry; Health Management and Policy; Biostatistics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Orthodontics; Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Economics; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9983995052502771
Metrics
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