Journal article
Maternal urinary tract infections and selected cardiovascular malformations
Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.464-473
06/2008
DOI: 10.1002/bdra.20460
PMID: 18452156
Abstract
BACKGROUND: In a population-based case-control study, we investigated the association between congenital cardiovascular malformations (CVMs) and maternal urinary tract infections (UTIs). METHODS: Within the National Birth Defects Prevention Study, 3,690 women who had singleton livebirths with nonsyndromic CVMs, and 4,760 women who had infants without birth defects were identified. Affected infants had: conotruncal, septal, anomalous pulmonary venous return, atrioventricular septal defects, or left- or right-sided obstructive heart defects. Mothers had a UTI if they reported having at least one infection during the first trimester. Adjusted ORs and 95% CIs were computed to determine the association between CVMs and UTIs. Stratified analyses were conducted to investigate if sulfonamide use and/or fever modified the effect between CVMs and UTIs. RESULTS: Women who had offspring with either left ventricular outflow tract obstructive defects or atrioventricular septal defects were more likely than controls to report a UTI. These associations remained among women who did not have fever or used sulfonamides. Maternal use of sulfonamides during the UTI did not appear to modify the relationship between CVM subtypes and maternal UTIs. CONCLUSIONS: In the National Birth Defects Prevention Study there was little evidence to support an association between CVMs and UTIs during the first trimester of pregnancy. Associations between left ventricular outflow tract obstructive defects and maternal UTI as well as between atrioventricular septal defects and maternal UTI were found. Our findings, while not conclusive, suggest that the possible association between maternal UTI and CVMs should be investigated further.
Details
- Title: Subtitle
- Maternal urinary tract infections and selected cardiovascular malformations
- Creators
- Mario A Cleves - Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital, Little Rock, ArkansasSadia Malik - Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital, Little Rock, ArkansasShengping Yang - Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital, Little Rock, ArkansasTonia C Carter - School of Public Health, State University of New York at Albany, Albany, New YorkCharlotte A Hobbs - Arkansas Center for Birth Defects Research and Prevention, Department of Pediatrics, University of Arkansas for Medical Sciences, and Arkansas Children's Hospital, Little Rock, ArkansasNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth Defects Research Part A: Clinical and Molecular Teratology, Vol.66(6), pp.464-473
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/bdra.20460
- PMID
- 18452156
- ISSN
- 1542-0752
- eISSN
- 1096-9926
- Number of pages
- 10
- Language
- English
- Date published
- 06/2008
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214692702771
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