Maternal use of bupropion and risk for congenital heart defects

Sura Alwan; Jennita Reefhuis; Lorenzo D Botto; Sonja A Rasmussen; Adolfo Correa; Jan M Friedman; National Birth Defects Prevention Study

doi:10.1016/j.ajog.2010.02.015

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Maternal use of bupropion and risk for congenital heart defects

Journal article

Peer reviewed

Maternal use of bupropion and risk for congenital heart defects

Sura Alwan, Jennita Reefhuis, Lorenzo D Botto, Sonja A Rasmussen, Adolfo Correa, Jan M Friedman and National Birth Defects Prevention Study

American journal of obstetrics and gynecology, Vol.203(1), pp.52.e1-52.e6

2010

DOI: 10.1016/j.ajog.2010.02.015

PMID: 20417496

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Abstract

We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant. We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997–2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception. Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2–5.7; P = .01). We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results.

Pregnancy

birth defects

bupropion exposure

congenital heart defects

Details

Title: Subtitle: Maternal use of bupropion and risk for congenital heart defects
Creators: Sura Alwan - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Jennita Reefhuis - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Lorenzo D Botto - Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT
Sonja A Rasmussen - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Adolfo Correa - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA
Jan M Friedman - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: American journal of obstetrics and gynecology, Vol.203(1), pp.52.e1-52.e6
DOI: 10.1016/j.ajog.2010.02.015
PMID: 20417496
NLM abbreviation: Am J Obstet Gynecol
ISSN: 0002-9378
eISSN: 1097-6868
Publisher: Mosby, Inc
Grant note: Centers for Disease Control and Prevention
Language: English
Date published: 2010
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984213373202771

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