Journal article
Maternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa
Journal of reproductive immunology, Vol.101-102(1), pp.111-119
03/2014
DOI: 10.1016/j.jri.2013.06.004
PMCID: PMC4060772
PMID: 23998333
Abstract
Whereas histocompatibility is critical for transplantation, HLA histoincompatibility is associated with successful pregnancy. Literature on HLA sharing and preeclampsia has been inconsistent; most studies focused on maternal–paternal rather than maternal–fetal sharing. This study examines whether maternal–fetal histocompatibility is associated with preeclampsia, and whether effects vary by semen exposure history. This case–control study of nulliparous women was designed to examine associations among HLA sharing, semen exposure, and preeclampsia. 258 preeclampsia cases and 182 normotensive controls met the eligibility criteria. HLA typing for mother and baby was performed for HLA-A, -B, -C, -DRB1, and -DQB1. We further restricted our study sample to 224 mother–baby pairs who had complete HLA typing for all five genes. Seminal fluid exposure indexes incorporated information on type of practice, frequency, contraceptive use (for vaginal exposure) and ingestion practices (for oral exposure). Multivariate models were adjusted for BMI and education. HLA-A matching, Class I matching, and combined Class I and II matching were associated with increased odds of preeclampsia. Among women with low semen exposure, effects of Class I matching were amplified (HLA-A matching, OR=6.27, 95%CI=1.04, 37.97; Class I matching, OR=4.49 per one-match increase, 95%CI=1.89, 14.50). With moderate to high semen exposure, Class II matching effects predominated (HLA-DQB1, OR=3.22, 95%CI=1.04, 9.99; Class II, OR=1.76 per one-match increase, 95%CI=1.05, 2.98; and total matches, OR=1.45 per one-match increase, 95%CI=1.02, 2.06). We found consistent evidence that maternal–fetal HLA sharing was associated with preeclampsia in a pattern influenced by prior vaginal exposure to paternal seminal fluid.
Details
- Title: Subtitle
- Maternal–fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case–control study of nulliparous women in Iowa
- Creators
- Elizabeth W Triche - Department of Epidemiology, Brown University School of Public Health, Providence, RI 02912, USAKarisa K Harland - Department of Emergency Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USAElizabeth H Field - Veterans Affairs Medical Center, Iowa City, IA 52246, USALinda M Rubenstein - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USAAudrey F Saftlas - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Journal of reproductive immunology, Vol.101-102(1), pp.111-119
- DOI
- 10.1016/j.jri.2013.06.004
- PMID
- 23998333
- PMCID
- PMC4060772
- NLM abbreviation
- J Reprod Immunol
- ISSN
- 0165-0378
- eISSN
- 1872-7603
- Publisher
- Elsevier B.V
- Grant note
- name: National Institute of Child Health & Development, award: R01-HD39753
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Epidemiology; Emergency Medicine; Injury Prevention Research Center; Immunology; Law Faculty; Internal Medicine
- Record Identifier
- 9984094355802771
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