Journal article
Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine
European journal of pharmacology, Vol.530(1), pp.33-39
2006
DOI: 10.1016/j.ejphar.2005.11.043
PMID: 16386243
Abstract
Matrix metalloproteinases (MMP) are ubiquitous enzymes involved in extracellular matrix remodeling, and as a consequence in a number of physiological and pathological states, including development, wound healing and cancer. A crucial feature of cancer progression and metastasis is the disruption of extracellular matrix, and spreading of proliferating cancer cells. Modulation of MMP is a main target of cancer research. Using the mouse fibrosarcoma cell line WEHI 164, producing high amounts of MMP-2, we investigated whether we could modulate its production. We report that MMP-2 is under the control of nitric oxide (NO)/nitric oxide synthase (NOS) system. In addition, we show that NOS activity is controlled by opioids in a non-opioid receptor-related manner. Finally, we provide evidence that morphine, when administrated at low, non-toxic concentrations (<
10
−
9
M) attenuates MMP-2 activity. We conclude that, as morphine is able to decrease metalloproteinase activity via the NO/NOS system, it may have a place in the treatment of several sarcomas including fibrosarcoma.
Details
- Title: Subtitle
- Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine
- Creators
- Ahmad Shariftabrizi - Tehran University of Medical SciencesArtemissia-Phoebe Nifli - University of CreteMohammad Ansari - Tehran University of Medical SciencesFarshid Saadat - Tehran University of Medical SciencesMohammad Reza Ebrahimkhani - Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranNastaran Alizadeh - Tehran University of Medical SciencesAzadeh Nasseh - Tehran University of Medical SciencesVassilia-Ismini Alexaki - University of CreteAhmad Reza Dehpour - University of CreteElias Castanas - University of CreteMohammad Reza Khorramizadeh - Tehran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.530(1), pp.33-39
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.ejphar.2005.11.043
- PMID
- 16386243
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 2006
- Academic Unit
- Radiology
- Record Identifier
- 9984318684802771
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