Journal article
Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN
Journal of the American Society of Nephrology, Vol.27(5), pp.1278-1287
05/2016
DOI: 10.1681/asn.2015060612
PMCID: PMC4849835
PMID: 26567243
Abstract
Renal pathologists and nephrologists met on February 20, 2015 to establish an etiology/pathogenesis-based system for classification and diagnosis of GN, with a major aim of standardizing the kidney biopsy report of GN. On the basis of etiology/pathogenesis, GN is classified into the following five pathogenic types, each with specific disease entities: immune-complex GN, pauci-immune GN, antiglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy. The pathogenesis-based classification forms the basis of the kidney biopsy report. To standardize the report, the diagnosis consists of a primary diagnosis and a secondary diagnosis. The primary diagnosis should include the disease entity/pathogenic type (if disease entity is not known) followed in order by pattern of injury (mixed patterns may be present); score/grade/class for disease entities, such as IgA nephropathy, lupus nephritis, and ANCA GN; and additional features as detailed herein. A pattern diagnosis as the sole primary diagnosis is not recommended. Secondary diagnoses should be reported separately and include coexisting lesions that do not form the primary diagnosis. Guidelines for the report format, light microscopy, immunofluorescence microscopy, electron microscopy, and ancillary studies are also provided. In summary, this consensus report emphasizes a pathogenesis-based classification of GN and provides guidelines for the standardized reporting of GN.
Details
- Title: Subtitle
- Mayo Clinic/Renal Pathology Society Consensus Report on Pathologic Classification, Diagnosis, and Reporting of GN
- Creators
- Sanjeev Sethi - Mayo Clinic, Rochester, Minnesota sethi.sanjeev@mayo.edu fervenza.fernando@mayo.eduMark Haas - Mayo Clinic, Rochester, MinnesotaGlen S Markowitz - Mayo Clinic, Rochester, MinnesotaVivette D D'Agati - Mayo Clinic, Rochester, MinnesotaHelmut G Rennke - Mayo Clinic, Rochester, MinnesotaJ Charles Jennette - Mayo Clinic, Rochester, MinnesotaIngeborg M Bajema - Mayo Clinic, Rochester, MinnesotaCharles E Alpers - Mayo Clinic, Rochester, MinnesotaAnthony Chang - Mayo Clinic, Rochester, MinnesotaLynn D Cornell - Mayo Clinic, Rochester, MinnesotaFernando G Cosio - Mayo Clinic, Rochester, MinnesotaAgnes B Fogo - Mayo Clinic, Rochester, MinnesotaRichard J Glassock - Mayo Clinic, Rochester, MinnesotaSundaram Hariharan - Mayo Clinic, Rochester, MinnesotaNeeraja Kambham - Mayo Clinic, Rochester, MinnesotaDonna J Lager - Mayo Clinic, Rochester, MinnesotaNelson Leung - Mayo Clinic, Rochester, MinnesotaMichael Mengel - Mayo Clinic, Rochester, MinnesotaKarl A Nath - Mayo Clinic, Rochester, MinnesotaIan S Roberts - Mayo Clinic, Rochester, MinnesotaBrad H Rovin - Mayo Clinic, Rochester, MinnesotaSurya V Seshan - Mayo Clinic, Rochester, MinnesotaRichard J H Smith - Mayo Clinic, Rochester, MinnesotaPatrick D Walker - Mayo Clinic, Rochester, MinnesotaChristopher G Winearls - Mayo Clinic, Rochester, MinnesotaGerald B Appel - Mayo Clinic, Rochester, MinnesotaMariam P Alexander - Mayo Clinic, Rochester, MinnesotaDaniel C Cattran - Mayo Clinic, Rochester, MinnesotaCarmen Avila Casado - Mayo Clinic, Rochester, MinnesotaH Terence Cook - Mayo Clinic, Rochester, MinnesotaAn S De Vriese - Mayo Clinic, Rochester, MinnesotaJai Radhakrishnan - Mayo Clinic, Rochester, MinnesotaLorraine C Racusen - Mayo Clinic, Rochester, MinnesotaPierre Ronco - Mayo Clinic, Rochester, MinnesotaFernando C Fervenza - Mayo Clinic, Rochester, Minnesota
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Nephrology, Vol.27(5), pp.1278-1287
- DOI
- 10.1681/asn.2015060612
- PMID
- 26567243
- PMCID
- PMC4849835
- NLM abbreviation
- J Am Soc Nephrol
- ISSN
- 1533-3450
- eISSN
- 1533-3450
- Publisher
- United States
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006354602771
Metrics
96 Record Views