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McKittrick-Wheelock syndrome presenting with dermatomyositis and rectal prolapse
Journal article   Open access   Peer reviewed

McKittrick-Wheelock syndrome presenting with dermatomyositis and rectal prolapse

Maen Aboul Hosn, Mohamad Khalife and Mohamad A Eloubeidi
Clinical and experimental gastroenterology, Vol.6(1), pp.85-89
06/2013
DOI: 10.2147/CEG.S45573
PMCID: PMC3697959
PMID: 23825927
url
https://doi.org/10.2147/CEG.S45573View
Published (Version of record) Open Access

Abstract

McKittrick–Wheelock syndrome is a rare disease characterized by a large hypersecretory rectosigmoid villous adenoma resulting in persistent large volume diarrhea, electrolyte abnormalities, and renal dysfunction. We report an unusual presentation of this syndrome in a patient who developed persistent diarrhea along with dermatomyositis and rectal prolapse and was later discovered to have a large rectal villous adenoma along with a smaller sigmoid tubulovillous adenoma. In our literature review, we were able to find one case report of a dermatomyositis occurring in conjunction with a tubulovillous adenoma and few case reports of rectal prolapse in the setting of a secretory villous adenoma. However, there were no reports on both occurring in association with McKittrick–Wheelock syndrome. This report highlights the variable manifestations of colorectal adenomas and the importance of searching for an underlying neoplastic entity in patients with new onset dermatomyositis or rectal prolapse or both.

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