Journal article
Measured Gene-by-Environment Interaction in Relation to Attention-Deficit/Hyperactivity Disorder
Journal of the American Academy of Child and Adolescent Psychiatry, Vol.49(9), pp.863-873
2010
DOI: 10.1016/j.jaac.2010.01.025
PMCID: PMC2928573
PMID: 20732623
Abstract
To summarize and evaluate the state of knowledge regarding the role of measured gene-by-environment interactions in relation to attention-deficit/hyperactivity disorder.
A selective review of methodologic issues was followed by a systematic search for relevant articles on measured gene-by-environment interactions; the search yielded 16 studies, which are discussed in qualitative fashion.
Relatively consistent evidence points to the interaction of genotype with psychosocial factors in the development of attention-deficit/hyperactivity disorder. The next step is to identify the mechanisms on the environment side and the gene combinations on the genetic side accounting for this effect. In contrast, evidence for gene-by-environment interactions involving pre- and perinatal risk factors is generally negative or unreplicated. The aggregate effect size for psychosocial interaction with genotype is more than double that for the interaction of pre- and perinatal risks with genotype. Only a small fraction of candidate environments and gene markers has been studied, and multivariate methods to integrate multiple gene or environment markers have yet to be implemented.
Gene-by-environment interaction appears likely to prove fruitful in understanding the etiology of attention-deficit/hyperactivity disorder. Findings to date already suggest new avenues of investigation particularly involving psychosocial mechanisms and their interplay with genotype. Further pursuit of theoretically promising leads is recommended.
Details
- Title: Subtitle
- Measured Gene-by-Environment Interaction in Relation to Attention-Deficit/Hyperactivity Disorder
- Creators
- Joel Nigg - Oregon Health and Science UniversityMolly Nikolas - Michigan State UniversityS. Alexandra Burt - Michigan State University
- Resource Type
- Journal article
- Publication Details
- Journal of the American Academy of Child and Adolescent Psychiatry, Vol.49(9), pp.863-873
- DOI
- 10.1016/j.jaac.2010.01.025
- PMID
- 20732623
- PMCID
- PMC2928573
- NLM abbreviation
- J Am Acad Child Adolesc Psychiatry
- ISSN
- 0890-8567
- eISSN
- 1527-5418
- Publisher
- Elsevier Inc
- Grant note
- R01 59105 / NIMH
- Language
- English
- Date published
- 2010
- Academic Unit
- Psychological and Brain Sciences; Injury Prevention Research Center
- Record Identifier
- 9984002325202771
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