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Measurement of Aryl and Alcohol Sulfotransferase Activity
Journal article

Measurement of Aryl and Alcohol Sulfotransferase Activity

Jonathan J. Sheng, Vyas Sharma and Michael W. Duffel
Current Protocols in Toxicology, Vol.8(1), pp.4.5.1-4.5.9
05/2001
DOI: 10.1002/0471140856.tx0405s08

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Abstract

Two methods are presented for determining the catalytic activity of aryl and alcohol sulfotransferases. The first assay is a simple and rapid procedure that is based on the extraction of a paired ion formed between the product organic sulfate and methylene blue. The second method employs HPLC analysis of the substrate‐dependent formation of PAP, an assay that is particularly useful when the sulfuric acid ester product is chemically unstable.

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