Journal article
Measurement of blood-brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium-dtpa
Magnetic resonance in medicine, Vol.27(1), pp.68-75
09/1992
DOI: 10.1002/mrm.1910270108
PMID: 1435211
Abstract
Sequential MR imaging with gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) and sequential measurements of plasma Gd-DTPA concentration by inductively coupled plasma atomic emission spectroscopy (ICP-AES) were used to estimate the blood-to-tissue transport coefficient (Ki) in the 36B-10 rat glioma model. For these measurements, tissue Gd-DTPA concentration was estimated from tumor enhancement by correlation with calibration measurements obtained by ICP-AES analysis of tumor tissue. The 14 animals for which Ki, was calculated can be grouped into those imaged at 11 days following tumor implantation, at 13-18 days, and at 20 days. The mean (+SEM) Ki values for these groups were 1.1 + 0.24, 9.2 + 0.8, and 13.4 + 1.7 ml/kg-min, respectively. These results correspond well with published data obtained by quantitative autoradiography. It is concluded that frequent sequential imaging and a graphical approach to Ki, calculation are promising methods for determining the blood-to-tissue transport coefficient noninvasively by contrastenhanced MRI.
Details
- Title: Subtitle
- Measurement of blood-brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium-dtpa
- Creators
- James Kenney - University of WashingtonUdo Schmiedl - University of WashingtonKenneth Maravilla - University of WashingtonFrank Starr - University of WashingtonMichael Graham - University of WashingtonAlexander Spence - University of WashingtonJames Nelson - University of Washington
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.27(1), pp.68-75
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- DOI
- 10.1002/mrm.1910270108
- PMID
- 1435211
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Number of pages
- 8
- Language
- English
- Date published
- 09/1992
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984312962602771
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