Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis

Rohit Bakshi; Venkata S R Dandamudi; Mohit Neema; Chitradeep De; Robert A Bermel

doi:10.1177/1051228405283901

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Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis

Journal article

Peer reviewed

Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis

Rohit Bakshi, Venkata S R Dandamudi, Mohit Neema, Chitradeep De and Robert A Bermel

Journal of neuroimaging, Vol.15(4 Suppl), pp.30S-45S

10/2005

DOI: 10.1177/1051228405283901

PMID: 16385017

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Abstract

Evaluation of brain and spinal cord atrophy by magnetic resonance imaging (MRI) has become an increasingly important component of understanding the multiple sclerosis (MS) disease process. These destructive aspects of the disease develop early in the disease course. A growing body of data links brain and spinal cord atrophy to clinical impairment more closely than can be linked with conventional measures of overt lesions. Thus, irreversible tissue damage may be a key factor leading to disease progression. In this review, the authors present the proposed mechanisms leading to central nervous system (CNS) atrophy. They describe the available MRI-based techniques to measure regional and global atrophy of the brain and spinal cord. They compare the rate of atrophy among MS phenotypes and summarize the emerging data linking atrophy to neurological and neuropsychological impairment. Finally, they discuss the effect of disease-modifying immunotherapies on the rate of CNS atrophy in patients with MS. Future research to clarify the etiology and pathophysiology of brain and spinal cord atrophy should provide new targets for therapeutic development.

Atrophy

Brain - pathology

Disability Evaluation

Disease Progression

Humans

Immunotherapy

Magnetic Resonance Imaging - methods

Monitoring, Physiologic - methods

Multiple Sclerosis - pathology

Multiple Sclerosis - therapy

Spinal Cord - pathology

Details

Title: Subtitle: Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis
Creators: Rohit Bakshi - Cleveland Clinic
Venkata S R Dandamudi - Cleveland Clinic
Mohit Neema - Cleveland Clinic
Chitradeep De - Brigham and Women's Hospital
Robert A Bermel - Cleveland Clinic
Resource Type: Journal article
Publication Details: Journal of neuroimaging, Vol.15(4 Suppl), pp.30S-45S
DOI: 10.1177/1051228405283901
PMID: 16385017
ISSN: 1051-2284
eISSN: 1552-6569
Language: English
Date published: 10/2005
Academic Unit: Psychiatry
Record Identifier: 9984627349502771

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