Measurement of prothrombin mRNA during gestation and early neonatal development

C T Kisker; S Perlman; D Bohlken; B Wicklund

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Measurement of prothrombin mRNA during gestation and early neonatal development

Journal article

Peer reviewed

Measurement of prothrombin mRNA during gestation and early neonatal development

C T Kisker, S Perlman, D Bohlken and B Wicklund

The Journal of laboratory and clinical medicine, Vol.112(4), pp.407-412

10/1988

PMID: 2459278

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Abstract

Prothrombin levels in the fetal and newborn lamb follow a gestational age-related pattern of development. The changes in activity are reflected by similar changes in prothrombin antigen concentration. Our investigations indicate that these changes in prothrombin antigen and activity levels are paralleled by changes in the levels of prothrombin messenger RNA present in liver samples from fetuses of various gestational ages.

Pregnancy

RNA

RNA, Antisense

Prothrombin - analysis

RNA, Messenger - analysis

Vitamin K Deficiency - blood

Embryonic and Fetal Development

Gestational Age

RNA Probes

Animals

Female

Prothrombin - genetics

Sheep

Details

Title: Subtitle: Measurement of prothrombin mRNA during gestation and early neonatal development
Creators: C T Kisker - University of Iowa, Stead Family Department of Pediatrics
S Perlman - University of Iowa, Microbiology and Immunology
D Bohlken
B Wicklund
Resource Type: Journal article
Publication Details: The Journal of laboratory and clinical medicine, Vol.112(4), pp.407-412
PMID: 2459278
NLM abbreviation: J Lab Clin Med
ISSN: 0022-2143
eISSN: 1532-6543
Publisher: United States
Grant note: 5 RO1 HD12574-09 / NICHD NIH HHS R01 HL39097-01 / NHLBI NIH HHS
Language: English
Date published: 10/1988
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777470002771

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