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Measuring Comorbidity in Cardiovascular Research: A Systematic Review
Journal article   Open access   Peer reviewed

Measuring Comorbidity in Cardiovascular Research: A Systematic Review

Harleah G. Buck, Jabar A. Akbar, Sarah Jingying Zhang and Janet A. Prvu Bettger
Nursing Research and Practice, Vol.2013, pp.1-11
01/01/2013
DOI: 10.1155/2013/563246
PMCID: PMC3730163
PMID: 23956853
url
https://doi.org/10.1155/2013/563246View
Published (Version of record) Open Access

Abstract

Background. Everything known about the roles, relationships, and repercussions of comorbidity in cardiovascular disease is shaped by how comorbidity is currently measured. Objectives. To critically examine how comorbidity is measured in randomized controlled trials or clinical trials and prospective observational studies in acute myocardial infarction (AMI), heart failure (HF), or stroke. Design. Systematic review of studies of hospitalized adults from MEDLINE CINAHL, PsychINFO, and ISI Web of Science Social Science databases. At least two reviewers screened and extracted all data. Results. From 1432 reviewed abstracts, 26 studies were included (AMI n = 8, HF n = 11, stroke n = 7). Five studies used an instrument to measure comorbidity while the remaining used the presence or absence of an unsubstantiated list of individual diseases. Comorbidity data were obtained from 1–4 different sources with 35% of studies not reporting the source. A year-by-year analysis showed no changes in measurement. Conclusions. The measurement of comorbidity remains limited to a list of conditions without stated rationale or standards increasing the likelihood that the true impact is underestimated.

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