Journal article
Measuring Executive Dysfunction Longitudinally and in Relation to Genetic Burden, Brain Volumetrics, and Depression in Prodromal Huntington Disease
Archives of clinical neuropsychology, Vol.28(2), pp.156-168
03/01/2013
DOI: 10.1093/arclin/acs105
PMCID: PMC3569950
PMID: 23246934
Abstract
Executive dysfunction (ED) is a characteristic of Huntington disease (HD), but its severity and progression is less understood in the prodromal phase, e.g., before gross motor abnormalities. We examined planning and problem-solving abilities using the Towers Task in HD mutation-positive individuals without motor symptoms (n 781) and controls (n 212). Participants with greater disease progression (determined using mutation size and current age) performed more slowly and with less accuracy on the Towers Task. Performance accuracy was negatively related to striatal volume while both accuracy and working memory were negatively related to frontal white matter volume. Disease progression at baseline was not associated with longitudinal performance over 4 years. Whereas the baseline findings indicate that ED becomes more prevalent with greater disease progression in prodromal HD and can be quantified using the Towers task, the absence of notable longitudinal findings indicates that the Towers Task exhibits limited sensitivity to cognitive decline in this population.
Details
- Title: Subtitle
- Measuring Executive Dysfunction Longitudinally and in Relation to Genetic Burden, Brain Volumetrics, and Depression in Prodromal Huntington Disease
- Creators
- Kathryn V. Papp - Harvard UniversityPeter J. Snyder - Brown UniversityJames A. Mills - University of IowaKevin Duff - University of UtahHolly J. Westervelt - Brown UniversityJeffrey D. Long - University of IowaSpencer Lourens - University of IowaJane S. Paulsen - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Archives of clinical neuropsychology, Vol.28(2), pp.156-168
- DOI
- 10.1093/arclin/acs105
- PMID
- 23246934
- PMCID
- PMC3569950
- NLM abbreviation
- Arch Clin Neuropsychol
- ISSN
- 0887-6177
- eISSN
- 1873-5843
- Publisher
- Oxford Univ Press
- Number of pages
- 13
- Grant note
- NS40068 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS040068 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) CHDI Foundation, Inc. R01HG003330 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) 2RO1 NS0040068 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 03/01/2013
- Academic Unit
- Psychiatry; Psychological and Brain Sciences; Biostatistics
- Record Identifier
- 9984280876502771
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