Journal article
Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges
The American journal of clinical nutrition, Vol.95(3), pp.539-547
03/01/2012
DOI: 10.3945/ajcn.111.015545
PMCID: PMC3278237
PMID: 22301922
Abstract
Whereas moderate drinking may have health benefits, excessive alcohol consumption causes many important acute and chronic diseases and is the third leading contributor to preventable death in the United States. Twin studies suggest that alcohol-consumption patterns are heritable (50%); however, multiple genetic variants of modest effect size are likely to contribute to this heritable variation. Genome-wide association studies provide a tool for discovering genetic loci that contribute to variations in alcohol consumption. Opportunities exist to identify susceptibility loci with modest effect by meta-analyzing together multiple studies. However, existing studies assessed many different aspects of alcohol use, such as typical compared with heavy drinking, and these different assessments can be difficult to reconcile. In addition, many studies lack the ability to distinguish between lifetime and recent abstention or to assess the pattern of drinking during the week, and a variety of such concerns surround the appropriateness of developing a common summary measure of alcohol intake. Combining such measures of alcohol intake can cause heterogeneity and exposure misclassification, cause a reduction in power, and affect the magnitude of genetic association signals. In this review, we discuss the challenges associated with harmonizing alcohol-consumption data from studies with widely different assessment instruments, with a particular focus on large-scale genetic studies. Am J Clin Nutr 2012; 95: 539-47.
Details
- Title: Subtitle
- Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges
- Creators
- Arpana Agrawal - Washington University in St. LouisNeal D. Freedman - National Institutes of HealthYu-Ching Cheng - University of Maryland, College ParkPeng Lin - Washington University in St. LouisJohn R. Shaffer - University of PittsburghQi Sun - Harvard UniversityKira Taylor - University of Louisville HospitalBrian Yaspan - Vanderbilt UniversityJohn W. Cole - University of Maryland, College ParkMarilyn C. Cornelis - Harvard UniversityRebecca S. DeSensi - University of PittsburghAnnette Fitzpatrick - National Human Genome Research InstituteGerardo Heiss - University of North CarolinaJae H. Kang - Harvard UniversityJeffrey O'Connell - University of Maryland, College ParkSiiri Bennett - University of WashingtonEbony Bookman - National Human Genome Research InstituteKathleen K. Bucholz - Washington University in St. LouisNeil Caporaso - National Institutes of HealthRichard Crout - West Virginia UniversityDanielle M. Dick - Virginia Commonwealth UniversityHoward J. Edenberg - Indiana UniversityAlison Goate - Washington University in St. LouisVictor Hesselbrock - University of ConnecticutSteven Kittner - University of Maryland, College ParkJohn Kramer - University of IowaJohn I. Nurnberger - Indiana UniversityLu Qi - Harvard UniversityJohn P. Rice - Washington University in St. LouisMarc Schuckit - University of California San DiegoRob M. van Dam - Harvard UniversityEric Boerwinkle - The University of Texas at AustinFrank Hu - Harvard UniversitySteven Levy - University of IowaMary Marazita - University of PittsburghBraxton D. Mitchell - University of Maryland, College ParkLouis R. Pasquale - Harvard UniversityLaura J. Bierut - Washington University in St. LouisGENEVA Consortium
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.95(3), pp.539-547
- DOI
- 10.3945/ajcn.111.015545
- PMID
- 22301922
- PMCID
- PMC3278237
- NLM abbreviation
- Am J Clin Nutr
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Grant note
- HHSN268201100005C; HHSN268201100006C; HHSN268201100007C; HHSN268201100008C; HHSN268201100009C; HHSN268201100010C; HHSN268201100011C; HHSN268201100012C / National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U01HG04424 / NIH GEI U01 HG004422 / NIH Genes, Environment and Health Initiative (GEI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U01-DE018903 / National Institutes of Dental and Craniofacial Research (NIDCR) as part of the trans-NIH GEI R01EY015473 / NATIONAL EYE INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10AA008401 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) Iowa Fluoride Study NIDCR through CIDR's NIH National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) HHSN268200782096C / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ABMRF/Foundation for Alcohol Research R01NS045012 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission Medical Research Service and the Baltimore Geriatrics Research, Education and Clinical Center of the Department of Veterans Affairs; US Department of Veterans Affairs T32AG000262 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) U01HG004446 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) U01HG004728; NEI R01EY015473 / NHGRI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) U01 HG004436 / National Human Genome Research Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) P30DK046200 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) U01HG004438 / Johns Hopkins University Center for Inherited Disease Research by NIH GEI P01CA089392 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) K99HL098459 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Office of Research and Development U01DE018903 / NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) R01DE014899 / NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) K02DA021237 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission American Heart Association Scientist Development Award; American Heart Association R01 NS45012; U01 NS069208-01 / NIH Office of Research on Women's Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Office of Research on Women's Health (ORWH) DK46200; U01HG004399; NIH R01 HL71981; K99HL098459 / Boston Obesity Nutrition Research Center R01-DE 014899; R01-DE09551; R01-DE12101 / NIDCR; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) Iowa Bone Development Study Gene, Environment Association Studies (GENEVA) under GEI Canadian Institutes of Health Research (MCC); Canadian Institutes of Health Research (CIHR)
- Language
- English
- Date published
- 03/01/2012
- Academic Unit
- Preventive and Community Dentistry; Psychiatry; Epidemiology
- Record Identifier
- 9984367653602771
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