Journal article
Measuring compensation in neurodegeneration using MRI
Current opinion in neurology, Vol.30(4), pp.380-387
08/01/2017
DOI: 10.1097/WCO.0000000000000469
PMCID: PMC5837021
PMID: 28537993
Abstract
Purpose of reviewDespite signs of cortical and subcortical loss, patients with prodromal and early-stage neurodegenerative disease are able to perform at a level comparable to the normal population. It is presumed that the onset of compensatory processes, that is changes in brain activation within a function-specific network or in the recruitment of a region outside of the task-network, underlies this maintenance of normal performance. However, in most studies to date, increased brain activity is not correlated with indices of both disease and performance and what appears to be compensation could simply be a symptom of neurodegeneration.Recent findingsMRI studies have explored compensation in neurodegenerative disease, claiming that compensation is evident across a number of disorders, including Alzheimer's and Parkinson's disease, but generally always in early stages; after this point, compensation is generally no longer able to operate under the severe burden of disease. However, none of these studies explicitly adopted a particular model of compensation. Thus, we also discuss our recent attempts to operationalize compensation for empirical testing.SummaryThere is clear evidence of compensatory processes in the early stages of neurodegenerative disease. However, for a more complete understanding, this requires more explicit empirical modelling.
Details
- Title: Subtitle
- Measuring compensation in neurodegeneration using MRI
- Creators
- Sarah Gregory - UCL Institute of NeurologyJeffrey D. Long - Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USASarah J. Tabrizi - UCL Inst Neurol, Huntingtons Dis Res Ctr, 2nd Floor,Russell Sq House,10-12 Russell Sq, London WC1B 5EH, EnglandGeraint Rees - Wellcome Trust
- Resource Type
- Journal article
- Publication Details
- Current opinion in neurology, Vol.30(4), pp.380-387
- DOI
- 10.1097/WCO.0000000000000469
- PMID
- 28537993
- PMCID
- PMC5837021
- NLM abbreviation
- Curr Opin Neurol
- ISSN
- 1350-7540
- eISSN
- 1473-6551
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- MR/P007015/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 100227/Z/12/Z / Wellcome Trust; European Commission CHDI foundation 200181/Z/15/Z / Wellcome Trust; European Commission
- Language
- English
- Date published
- 08/01/2017
- Academic Unit
- Psychiatry; Biostatistics
- Record Identifier
- 9984280873102771
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