Journal article
Measuring muscle blood flow: a key link between systemic and regional metabolism
Current opinion in clinical nutrition and metabolic care, Vol.11(5), pp.580-586
09/2008
DOI: 10.1097/MCO.0b013e32830b5b34
PMCID: PMC3462349
PMID: 18685453
Abstract
PURPOSE OF REVIEWTo provide a brief overview of the main techniques to measure muscle blood flow in humans and highlight some of the strengths and weaknesses associated with each technique.
RECENT FINDINGSPeak muscle blood flow values of 300 ml/min per 100 g are possible in humans during heavy exercise performed with small muscle mass. This value is far higher than that which appears in most textbooks. Accurate and reliable techniques are therefore essential in measuring muscle blood flow. Current invasive techniques commonly used include indicator dilution (thermodilution and dye dilution) and radiolabel tracer washout (e.g. Xe washout) methods. Although invasive techniques have provided valuable insight into tissue blood flow, noninvasive techniques such as venous occlusion plethysmography and Doppler ultrasound are frequently used and provide accurate measurements of blood flow. Newer imaging techniques (MRI, positron emission tomography, and contrast-enhanced ultrasonography) promise increased resolution of measurements of local blood flow, including in discrete tissues in which more classical techniques are not able to be used.
SUMMARYMuscle blood flow is a key link in the interplay and regulation of systemic and local muscle metabolism. Recognizing the advantages and limitations of each technique is essential to translational researchers studying the effects of nutrition and metabolism on muscle blood flow.
Details
- Title: Subtitle
- Measuring muscle blood flow: a key link between systemic and regional metabolism
- Creators
- Darren Casey - Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USATimothy CurryMichael Joyner
- Resource Type
- Journal article
- Publication Details
- Current opinion in clinical nutrition and metabolic care, Vol.11(5), pp.580-586
- DOI
- 10.1097/MCO.0b013e32830b5b34
- PMID
- 18685453
- PMCID
- PMC3462349
- NLM abbreviation
- Curr Opin Clin Nutr Metab Care
- ISSN
- 1363-1950
- eISSN
- 1473-6519
- Publisher
- Lippincott Williams & Wilkins, Inc
- Language
- English
- Date published
- 09/2008
- Academic Unit
- Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984046832102771
Metrics
31 Record Views