Journal article
Measuring tinnitus in pharmaceutical clinical trials
The Journal of the Acoustical Society of America, Vol.152(6), pp.3843-3849
12/2022
DOI: 10.1121/10.0014699
PMID: 36586833
Abstract
This paper reviews methods and considerations for measuring tinnitus in clinical trials designed to evaluate treatment options using investigational medicinal products. Tests applied in tinnitus-related research and clinical practice have their own measurement purposes, advantages, and limitations. If the characteristics of each test method are well understood, the test can be effectively used in clinical trials. For the accuracy of clinical trial results, it is necessary to use a test tool with verified validity, reliability, and sensitivity. If a test tool that is likely to have high variability in the same individual is required in the clinical trial, strategies to increase the reliability of the test, such as repeat measurements, may also be needed. In addition, a test tool that meets the purpose of the clinical trial should be selected. For example, the tinnitus questionnaire is appropriate to assess reactions to tinnitus, and measurements of tinnitus loudness or pitch are appropriate to evaluate the psychoacoustic characteristics of tinnitus. In conclusion, the use of validated test tools that meet the purpose of the trial will help with the accuracy of the clinical trial results.
Details
- Title: Subtitle
- Measuring tinnitus in pharmaceutical clinical trials
- Creators
- In-Ki Jin - Hallym UniversityRichard S Tyler - Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- The Journal of the Acoustical Society of America, Vol.152(6), pp.3843-3849
- DOI
- 10.1121/10.0014699
- PMID
- 36586833
- ISSN
- 0001-4966
- eISSN
- 1520-8524
- Grant note
- DOI: 10.13039/501100003725, name: the National Research Foundation of Korea, award: 2022R1H1A2091291
- Language
- English
- Date published
- 12/2022
- Academic Unit
- Communication Sciences and Disorders; Otolaryngology; University College Courses
- Record Identifier
- 9984354958102771
Metrics
13 Record Views