Journal article
Mechanical and Temperature Stressor-Induced Seizure-and-Paralysis Behaviors in Drosophila Bang-Sensitive Mutants
Journal of neurogenetics, Vol.26(2), pp.189-197
06/01/2012
DOI: 10.3109/01677063.2012.690011
PMID: 22716921
Abstract
"Bang-sensitive" mutants of Drosophila display characteristic repertoires of distinct seizure-and-paralysis behaviors upon mechanical shock (Ganetzky & Wu, 1982, Genetics, 100, 597-614). The authors found that each of the bang-sensitive mutants described in this paper (bas, bss, eas, and tko) also displayed similar behavioral repertoires upon exposure to either high or low temperature. These repertoires are composed of interspersed periods of seizure and paralysis, and appear to have interesting parallels with vertebrate epileptiform behavior. Analysis of gynandromorph mosaics of these bang-sensitive mutant flies indicated that anatomical foci required for these two types of behaviors do not totally overlap, as they were separable among mosaic flies. Observations on mosaic and decapitated flies demonstrated an all-or-none expression of the seizure-and-paralysis behaviors, indicating global activity and long-range interactions in the nervous system. Therefore, the diverse collection of currently available Drosophila bang-sensitive mutants may serve as a rich source for mutational and cellular analysis to identify interacting molecular networks that are responsible for seizure phenotypes.
Details
- Title: Subtitle
- Mechanical and Temperature Stressor-Induced Seizure-and-Paralysis Behaviors in Drosophila Bang-Sensitive Mutants
- Creators
- Martin G Burg - PhD Program in GeneticsChun-Fang Wu - Department of Biology, University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neurogenetics, Vol.26(2), pp.189-197
- Publisher
- Taylor & Francis
- DOI
- 10.3109/01677063.2012.690011
- PMID
- 22716921
- ISSN
- 0167-7063
- eISSN
- 1563-5260
- Language
- English
- Date published
- 06/01/2012
- Academic Unit
- Iowa Neuroscience Institute; Biology
- Record Identifier
- 9984070709102771
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