Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies

Fatiesa Sulejmani; Anastassia Pokutta-Paskaleva; Olga Salazar; Mohsen Karimi; Wei Sun

doi:10.1016/j.jmbbm.2018.08.053

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Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies

Journal article

Peer reviewed

Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies

Fatiesa Sulejmani, Anastassia Pokutta-Paskaleva, Olga Salazar, Mohsen Karimi and Wei Sun

Journal of the mechanical behavior of biomedical materials, Vol.89, pp.9-12

01/01/2019

DOI: 10.1016/j.jmbbm.2018.08.053

PMCID: PMC6223622

PMID: 30236979

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Abstract

Congenital Heart Disease (CHD) is the leading cause of pediatric mortality, with many cases affecting the right ventricular outflow tract (RVOT) or pulmonary valve (PV). Understanding the mechanics of the disease condition can provide insight into development of durable repair techniques and bioengineered replacement devices. This work presents a mechanical and structural analysis of the pulmonary valve of two pediatric cases. Two PV tissues were excised as part of the operative procedure. One PV was obtained from a 9-month-old with Noonan syndrome (Patient 1) and the other from a 6-month-old with tricuspid atresia (Patient 2). The leaflets were subjected to planar biaxial tensile testing and second harmonic generation (SHG) imaging for mechanical and structural evaluation. Patient 1 exhibited a more anisotropic mechanical response than Patient 2, with sample stiffness on par with that of adult PV tissue. Additionally, both samples showed radial and circumferential alignment of collagen fibers on the ventricularis and fibrosa sides of the leaflets, respectively. Collagen fibers on the fibrosa side were also more crimped than on the ventricularis side.

Biomechanical Phenomena

Female

Heart Defects, Congenital - diagnostic imaging

Heart Defects, Congenital - pathology

Heart Defects, Congenital - physiopathology

Humans

Infant

Male

Mechanical Phenomena

Molecular Imaging

Pulmonary Valve - diagnostic imaging

Pulmonary Valve - pathology

Pulmonary Valve - physiopathology

Details

Title: Subtitle: Mechanical and structural analysis of the pulmonary valve in congenital heart defects: A presentation of two case studies
Creators: Fatiesa Sulejmani - The Wallace H. Coulter Department of Biomedical Engineering
Anastassia Pokutta-Paskaleva - The Wallace H. Coulter Department of Biomedical Engineering
Olga Salazar - Connecticut Children's Medical Center
Mohsen Karimi - Connecticut Children's Medical Center
Wei Sun - The Wallace H. Coulter Department of Biomedical Engineering
Resource Type: Journal article
Publication Details: Journal of the mechanical behavior of biomedical materials, Vol.89, pp.9-12
DOI: 10.1016/j.jmbbm.2018.08.053
PMID: 30236979
PMCID: PMC6223622
ISSN: 1751-6161
eISSN: 1878-0180
Grant note: R01 HL104080 / NHLBI NIH HHS R21 HL127570 / NHLBI NIH HHS
Language: English
Date published: 01/01/2019
Academic Unit: Cardiothoracic Surgery
Record Identifier: 9984557948602771

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