Journal article
Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft
Journal of biomaterials science. Polymer ed., Vol.24(3), pp.239-252
02/01/2013
DOI: 10.1080/09205063.2012.690273
PMID: 23565645
Abstract
The development of intimal hyperplasia is the major cause of failure of both autologous saphenous vein and synthetic coronary artery bypass grafts. This is partially due to graft-host vessel compliance mismatch. Cellulose and chitosan (CELL:CHIT) are both biocompatible, nontoxic, and naturally occurring biopolymers that have been used extensively for biomedical applications. Elastic properties of membranes made of CELL:CHIT blends with different ratios between each polymer were determined using uniaxial tests and the ratio that yielded the less stiff membrane was chosen to prepare a small diameter hollow tube. The presence of chitosan had a favorable impact on the elasticity of the membranes, where the CELL:CHIT 5:5 ratio showed the lowest Young's modulus. Small diameter tubular constructs were fabricated using this optimal CELL:CHIT ratio and the compliance was determined on samples with different wall thickness and internal diameter. The compliance of the hollow tube with inner diameter of 4 mm and wall thickness of 1.2 mm was found to be 5.91%/mmHg × 10
−2
, which is higher than those of Dacron, expanded polytetrafluorethylene, and saphenous vein, but very close to that of human coronary artery. Burst strength tests revealed that the tubes can withstand at least 300 mmHg. Finally, the tubes showed satisfactory cell attachment property when myofibroblast cells adhered and proliferated on the lumen of the samples.
Details
- Title: Subtitle
- Mechanical properties of cellulose: chitosan blends for potential use as a coronary artery bypass graft
- Creators
- Eduardo P Azevedo - Department of Pharmaceutics and Experimental Therapeutics , The University of IowaRohini Retarekar - Department of Biomedical Engineering , The University of IowaMadhavan L Raghavan - Department of Biomedical Engineering , The University of IowaVijay Kumar - Department of Pharmaceutics and Experimental Therapeutics , The University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of biomaterials science. Polymer ed., Vol.24(3), pp.239-252
- Publisher
- Routledge
- DOI
- 10.1080/09205063.2012.690273
- PMID
- 23565645
- ISSN
- 0920-5063
- eISSN
- 1568-5624
- Language
- English
- Date published
- 02/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Pharmacy
- Record Identifier
- 9984064254102771
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