Journal article
Mechanical properties of murine and porcine ocular tissues in compression
Experimental Eye Research, Vol.121, pp.194-199
04/2014
DOI: 10.1016/j.exer.2014.02.020
PMCID: PMC3997121
PMID: 24613781
Abstract
Sub-retinal implantation of foreign materials is becoming an increasingly common feature of novel therapies for retinal dysfunction. The ultimate compatibility of implants depends not only on their in vitro chemical compatibility, but also on how well the mechanical properties of the material match those of the native tissue. In order to optimize the mechanical properties of retinal implants, the mechanical properties of the mammalian retina itself must be carefully characterized. In this study, the compressive moduli of eye tissues, especially the retina, were probed using a dynamic mechanical analysis instrument in static mode. The retinal compressive modulus was lower than that of the sclera or cornea, but higher than that of the RPE and choroid. Compressive modulus remained relatively stable with age. Conversely, apparent retinal softening occurred at an early age in mice with inherited retinal degeneration. Compressive modulus is an important consideration for the design of retinal implants. Polymer scaffolds with moduli that are substantially different than that of the native tissue in which they will ultimately reside will be less likely to aid in the differentiation and development of the appropriate cell types in vitro and will have reduced biocompatibility in vivo. •Estimate of modulus is critical for biomaterial selection and transplantation.•Compressive moduli of sclera and cornea were higher than that of the retina.•Compressive modulus of the RPE and choroid was lower than that of the retina.•Tensile retinal modulus is 10 fold higher than compressive retinal modulus.•Retinal degeneration affects retinal compressive modulus.
Details
- Title: Subtitle
- Mechanical properties of murine and porcine ocular tissues in compression
- Creators
- Kristan S Worthington - Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, IA, USALuke A Wiley - Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USAAlexandra M Bartlett - Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, IA, USAEdwin M Stone - Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USARobert F Mullins - Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USAAliasger K Salem - Department of Pharmaceutics and Experimental Therapeutics, The University of Iowa, Iowa City, IA, USAC. Allan Guymon - Department of Chemical and Biochemical Engineering, The University of Iowa, Iowa City, IA, USABudd A Tucker - Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Experimental Eye Research, Vol.121, pp.194-199
- DOI
- 10.1016/j.exer.2014.02.020
- PMID
- 24613781
- PMCID
- PMC3997121
- NLM abbreviation
- Exp Eye Res
- ISSN
- 0014-4835
- eISSN
- 1096-0007
- Publisher
- Elsevier Ltd
- Grant note
- name: National Science Foundation; name: National Institute of Health New Innovators Award Program; name: Stephen A. Wynn Institute for Vision Research
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Ophthalmology and Visual Sciences
- Record Identifier
- 9983980063002771
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