Mechanical unloading of the failing heart exposes the dynamic nature of autophagy

Kari Wellnitz; Heinrich Taegtmeyer

doi:10.4161/auto.6.1.10538

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Mechanical unloading of the failing heart exposes the dynamic nature of autophagy

Journal article

Open access

Peer reviewed

Mechanical unloading of the failing heart exposes the dynamic nature of autophagy

Kari Wellnitz and Heinrich Taegtmeyer

Autophagy, Vol.6(1), pp.155-156

01/2010

DOI: 10.4161/auto.6.1.10538

PMID: 19949312

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Abstract

Mechanical unloading with a left-ventricular assist device decreases the energy demand of the failing human heart. Here, we describe our recent work showing that markers and mediators of autophagy in the failing heart are down-regulated by mechanical unloading. These observations are consistent with the concept that autophagy may be an adaptive mechanism to secure survival of the failing heart muscle cell.

Heart Failure - surgery

Membrane Proteins - genetics

Humans

Myocardial Contraction - physiology

Heart Failure - physiopathology

Cardiac Volume - physiology

Proto-Oncogene Proteins - genetics

Autophagy - physiology

Ventricular Remodeling - physiology

Biomechanical Phenomena

Animals

Membrane Proteins - physiology

Models, Biological

Proto-Oncogene Proteins - physiology

Ventricular Function, Left - physiology

Heart Function Tests

Heart-Assist Devices

Details

Title: Subtitle: Mechanical unloading of the failing heart exposes the dynamic nature of autophagy
Creators: Kari Wellnitz - Department of Medicine, Division of Cardiology, The University of Texas Medical School at Houston, Houston, TX, USA
Heinrich Taegtmeyer
Resource Type: Journal article
Publication Details: Autophagy, Vol.6(1), pp.155-156
DOI: 10.4161/auto.6.1.10538
PMID: 19949312
ISSN: 1554-8627
eISSN: 1554-8635
Language: English
Date published: 01/2010
Academic Unit: Critical Care; Stead Family Department of Pediatrics
Record Identifier: 9984093321102771

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