Mechanism of Hyperglycemia and Response to Treatment with an Inhibitor of Fatty Acid Oxidation in a Patient with Insulin Resistance due to Antiinsulin Receptor Antibodies

LAWRENCE MANDARINO; EVA TSALIKIAN; STEPHEN BARTOLD; HAROLD MARSH; AIDAN CARNEY; ELLEN BUERKLIN; GENE TUTWILER; MOREY HAYMOND; BARRY HANDWERGER; ROBERT RIZZA

doi:10.1210/jcem-59-4-658

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Mechanism of Hyperglycemia and Response to Treatment with an Inhibitor of Fatty Acid Oxidation in a Patient with Insulin Resistance due to Antiinsulin Receptor Antibodies

Journal article

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Mechanism of Hyperglycemia and Response to Treatment with an Inhibitor of Fatty Acid Oxidation in a Patient with Insulin Resistance due to Antiinsulin Receptor Antibodies

LAWRENCE MANDARINO, EVA TSALIKIAN, STEPHEN BARTOLD, HAROLD MARSH, AIDAN CARNEY, ELLEN BUERKLIN, GENE TUTWILER, MOREY HAYMOND, BARRY HANDWERGER and ROBERT RIZZA

The journal of clinical endocrinology and metabolism, Vol.59(4), pp.658-664

10/1984

DOI: 10.1210/jcem-59-4-658

PMID: 6480801

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Abstract

Severe hyperglycemia and insulin resistance due to antiinsulin receptor antibodies developed over a period of 3 months in a 50-yr-old insulin-requiring diabetic patient. The hyperglycemia resulted from overproduction of glucose due to excessive rates of glycogenolysis and gluconeogenesis rather than decreased glucose utilization. Treatment with methyl-2-tetradecylglycidate, an inhibitor of fatty acid oxidation, resulted in a decrease in plasma glucose concentration. This was associated with a decrease in the rate of glucose production due to decreases in both gluconeogenesis and glycogenolysis rates, as well as an increase in the respiratory quotient. Plasma glucose concentrations continued to respond to the drug for the next 2 months until the sudden development of terminal hypoglycemia. The hypoglycemic action of the drug is consistent with the existence of an insulin-independent effect of fatty acid oxidation on glucose metabolism in man.

Details

Title: Subtitle: Mechanism of Hyperglycemia and Response to Treatment with an Inhibitor of Fatty Acid Oxidation in a Patient with Insulin Resistance due to Antiinsulin Receptor Antibodies
Creators: LAWRENCE MANDARINO
EVA TSALIKIAN
STEPHEN BARTOLD
HAROLD MARSH
AIDAN CARNEY
ELLEN BUERKLIN
GENE TUTWILER
MOREY HAYMOND
BARRY HANDWERGER
ROBERT RIZZA
Resource Type: Journal article
Publication Details: The journal of clinical endocrinology and metabolism, Vol.59(4), pp.658-664
DOI: 10.1210/jcem-59-4-658
PMID: 6480801
ISSN: 0021-972X
eISSN: 1945-7197
Language: English
Date published: 10/1984
Academic Unit: Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984093341302771

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