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Mechanism of exercise-induced analgesia: what we can learn from physically active animals
Journal article   Open access   Peer reviewed

Mechanism of exercise-induced analgesia: what we can learn from physically active animals

Joseph B Lesnak and Kathleen A Sluka
Pain reports, Vol.5(5), pp.e850-e850
09/2020
DOI: 10.1097/PR9.0000000000000850
PMID: 33490844
url
https://doi.org/10.1097/PR9.0000000000000850View
Published (Version of record) Open Access

Abstract

Physical activity has become a first-line treatment in rehabilitation settings for individuals with chronic pain. However, research has only recently begun to elucidate the mechanisms of exercise-induced analgesia. Through the study of animal models, exercise has been shown to induce changes in the brain, spinal cord, immune system, and at the site of injury to prevent and reduce pain. Animal models have also explored beneficial effects of exercise through different modes of exercise including running, swimming, and resistance training. This review will discuss the central and peripheral mechanisms of exercise-induced analgesia through different modes, intensity, and duration of exercise as well as clinical applications of exercise with suggestions for future research directions.
Analgesia Central mechanisms Animal models Exercise Pain Peripheral mechanisms Hyperalgesia

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