Journal article
Mechanism of hypokalemia in magnesium deficiency
Journal of the American Society of Nephrology, Vol.18(10), pp.2649-2652
10/2007
DOI: 10.1681/ASN.2007070792
PMID: 17804670
Abstract
Magnesium deficiency is frequently associated with hypokalemia. Concomitant magnesium deficiency aggravates hypokalemia and renders it refractory to treatment by potassium. Herein is reviewed literature suggesting that magnesium deficiency exacerbates potassium wasting by increasing distal potassium secretion. A decrease in intracellular magnesium, caused by magnesium deficiency, releases the magnesium-mediated inhibition of ROMK channels and increases potassium secretion. Magnesium deficiency alone, however, does not necessarily cause hypokalemia. An increase in distal sodium delivery or elevated aldosterone levels may be required for exacerbating potassium wasting in magnesium deficiency.
Details
- Title: Subtitle
- Mechanism of hypokalemia in magnesium deficiency
- Creators
- Chou-Long Huang - UT Southwestern Medical Center, Department of Medicine, 5323 Harry Hines Boulevard, Dallas, TX 75390-8856, USA. chou-long.huang@utsouthwestern.eduElizabeth Kuo
- Resource Type
- Journal article
- Publication Details
- Journal of the American Society of Nephrology, Vol.18(10), pp.2649-2652
- DOI
- 10.1681/ASN.2007070792
- PMID
- 17804670
- NLM abbreviation
- J Am Soc Nephrol
- ISSN
- 1046-6673
- eISSN
- 1533-3450
- Grant note
- DK54368 / NIDDK NIH HHS DK59530 / NIDDK NIH HHS
- Language
- English
- Date published
- 10/2007
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094356202771
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