Journal article
Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis
Neuron (Cambridge, Mass.), Vol.52(4), pp.663-677
11/22/2006
DOI: 10.1016/j.neuron.2006.09.029
PMCID: PMC2673733
PMID: 17114050
Abstract
Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the time course, molecular design, and implementation of homeostatic signaling remain poorly defined. Here we demonstrate that a homeostatic increase in presynaptic neurotransmitter release can be induced within minutes following postsynaptic glutamate receptor blockade. The rapid induction of synaptic homeostasis is independent of new protein synthesis and does not require evoked neurotransmission, indicating that a change in the efficacy of spontaneous quantal release events is sufficient to trigger the induction of synaptic homeostasis. Finally, both the rapid induction and the sustained expression of synaptic homeostasis are blocked by mutations that disrupt the pore-forming subunit of the presynaptic CaV2.1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic CaV2.1 in a homeostatic retrograde signaling system.
Details
- Title: Subtitle
- Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis
- Creators
- C. Andrew Frank - Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158Matthew J Kennedy - Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158Carleton P Goold - Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158Kurt W Marek - Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158Graeme W Davis - Department of Biochemistry and Biophysics, Neuroscience Program, University of California, San Francisco, 1550 4th Street, Rock Hall 4th Floor North, San Francisco, California 94158
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.52(4), pp.663-677
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2006.09.029
- PMID
- 17114050
- PMCID
- PMC2673733
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 11/22/2006
- Academic Unit
- Anatomy and Cell Biology; Iowa Neuroscience Institute
- Record Identifier
- 9984025460402771
Metrics
17 Record Views