Journal article
Mechanisms and Management of Retinopathy of Prematurity
The New England journal of medicine, Vol.368(12), pp.1161-1163
03/21/2013
DOI: 10.1056/NEJMc1301021
PMID: 23514302
Abstract
To the Editor:
Hartnett and Penn (Dec. 27 issue)
1
describe mechanisms by which changes in oxygen tension contribute to retinopathy of prematurity. A major cause of vision loss in these patients remains retinal vasoproliferation into the vitreous, which causes vitreoretinal traction in the macula and retinal detachment. Fibronectin is expressed at the vitreoretinal interface. Cleavage of fibronectin induces posterior vitreous detachment, which decreases vitreoretinal traction and reduces the need for vitreoretinal surgery.
2
Autologous plasmin enzyme (which cleaves fibronectin to induce posterior vitreous detachment) that was administered during surgery for retinal detachment was associated with improved retinal reattachment and visual outcomes . . .
Details
- Title: Subtitle
- Mechanisms and Management of Retinopathy of Prematurity
- Creators
- Rajesh C Rao - Washington University School of Medicine, St. Louis, MOBrian J Dlouhy - University of Iowa Hospitals and Clinics, Iowa City, IABonny Jasani - KEM Hospital, Mumbai, IndiaRuchi Nanavati - KEM Hospital, Mumbai, IndiaNandkishor Kabra - KEM Hospital, Mumbai, IndiaM. Elizabeth Hartnett - University of Utah, Salt Lake City, UTJohn S Penn - Vanderbilt University School of Medicine, Nashville, TN
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.368(12), pp.1161-1163
- Publisher
- Massachusetts Medical Society
- DOI
- 10.1056/NEJMc1301021
- PMID
- 23514302
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Language
- English
- Date published
- 03/21/2013
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984070418602771
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