Journal article
Mechanisms and consequences of chromosomal translocation
Cancer epidemiology, biomarkers & prevention, Vol.17(8), pp.1849-1851
08/2008
DOI: 10.1158/1055-9965.EPI-07-2902
PMCID: PMC2562255
PMID: 18708370
Abstract
A 2006 National Cancer Institute workshop on chromosomal translocations brought together laboratory, clinical, and population scientists to cross-fertilize and catalyze research on this important disease process. The deliberations revealed significant contrasts between two types of translocations that result in either deregulated expression of oncogenes or formation of novel fusion genes. The classic oncogene-activating translocation, MYC-IGH, has been elucidated in terms of molecular structure and functional consequences yet has little epidemiologic characterization. In comparison, the archetypal fusion-gene translocation, BCR-ABL, has well-described clinical manifestations but is less defined with regard to mechanism of generation. Interdisciplinary collaboration on chromosomal translocations should yield additional insights regarding their biological significance and potential as targets for intervention.
Details
- Title: Subtitle
- Mechanisms and consequences of chromosomal translocation
- Creators
- Charles S Rabkin - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS/7082, Bethesda, MD 20892, USA. rabkinc@mail.nih.govSiegfried Janz
- Resource Type
- Journal article
- Publication Details
- Cancer epidemiology, biomarkers & prevention, Vol.17(8), pp.1849-1851
- DOI
- 10.1158/1055-9965.EPI-07-2902
- PMID
- 18708370
- PMCID
- PMC2562255
- ISSN
- 1055-9965
- eISSN
- 1538-7755
- Grant note
- P30 CA086862 / NCI NIH HHS Z01 CP010142-09 / Intramural NIH HHS
- Language
- English
- Date published
- 08/2008
- Academic Unit
- Pathology
- Record Identifier
- 9984083996702771
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