Journal article
Mechanisms linking mechanotransduction and cell metabolism
Current opinion in cell biology, Vol.54, pp.114-120
10/01/2018
DOI: 10.1016/j.ceb.2018.05.004
PMCID: PMC6487484
PMID: 29902730
Abstract
Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface adhesion receptors, such as the cadherins and integrins. Much attention has focused on identifying how these adhesion receptors transmit force. In contrast, less is known regarding how these force-activated pathways are integrated with other cellular processes. In this review, we describe how cadherins and integrins transmit force, and discuss how these adhesion receptors are linked to cell metabolism. We focus on understanding this connection by highlighting how the cadherins and integrins interact with a master regulator of energy homeostasis, AMP-activated protein kinase (AMPK) and its upstream activator, Liver Kinase B1 (LKB1). We consider why there is a need for force transmission to be coupled to metabolism and highlight the major unanswered questions in the field.
Details
- Title: Subtitle
- Mechanisms linking mechanotransduction and cell metabolism
- Creators
- Alicia M. Salvi - Roy J. and Lucille A. Carver College of MedicineKris A. DeMali - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Current opinion in cell biology, Vol.54, pp.114-120
- DOI
- 10.1016/j.ceb.2018.05.004
- PMID
- 29902730
- PMCID
- PMC6487484
- NLM abbreviation
- Curr Opin Cell Biol
- ISSN
- 0955-0674
- eISSN
- 1879-0410
- Publisher
- Current Biology Ltd
- Number of pages
- 7
- Grant note
- T32GM067795 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Alfred P. Sloan Fellowship; Alfred P. Sloan Foundation GM112805 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32 GM067795 / Predoctoral Training Grant in the Pharmacological Sciences
- Language
- English
- Date published
- 10/01/2018
- Academic Unit
- Dermatology; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology
- Record Identifier
- 9984293079502771
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