Journal article
Mechanisms of Airway Epithelial Ion Transport
Clinics in chest medicine, Vol.7(2), pp.273-283
06/1986
DOI: 10.1016/S0272-5231(21)00423-8
PMID: 2424665
Abstract
Airway epithelia contain the transport mechanisms required to effect either chloride secretion or sodium absorption. Thus, depending on the local neurohumoral environment, they have the ability to either secrete34 or absorb16 fluid. Therefore, they are in a unique position to precisely regulate the quantity and composition of the respiratory tract fluid. The importance of the respiratory tract fluid as a pulmonary defense mechanism is clear. This point is emphasized by the substantial morbidity and mortality that result from abnormalities of airway epithelial function in controlling the quantity and composition of fluid in diseases such as cystic fibrosis and asthma, and in conditions such as cigarette smoking. Therefore, it is essential to understand the function of the epithelium, its regulation, and the mechanism of ion transport at the level of the individual transport processes on the two cell membranes. As our understanding of the mechanism of ion transport increases, we may be able to define a more rational therapy of disease.
Details
- Title: Subtitle
- Mechanisms of Airway Epithelial Ion Transport
- Creators
- Michael J Welsh - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinics in chest medicine, Vol.7(2), pp.273-283
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0272-5231(21)00423-8
- PMID
- 2424665
- ISSN
- 0272-5231
- eISSN
- 1557-8216
- Language
- English
- Date published
- 06/1986
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Pulmonary, Critical Care, and Occupational Medicine; Fraternal Order of Eagles Diabetes Research Center; Neurosurgery; Internal Medicine
- Record Identifier
- 9984259509302771
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