Journal article
Mechanisms of Insulin Action on Sympathetic Nerve Activity
Clinical and experimental hypertension (1993), Vol.17(1-2), pp.39-50
1995
DOI: 10.3109/10641969509087053
PMID: 7735284
Abstract
Insulin resistance and hyperinsulinemia may contribute to the development of arterial hypertension. Although insulin may elevate arterial pressure, in part, through activation of the sympathetic nervous system, the sites and mechanisms of insulin-induced sympathetic excitation remain uncertain. While sympathoexcitation during insulin may be mediated by the baroreflex, or by modulation of norepinephrine release from sympathetic nerve endings, it has been shown repeatedly that insulin increases sympathetic outflow by actions on the central nervous system. Previous studies employing norepinephrine turnover have suggested that insulin causes sympathoexcitation by acting in the hypothalamus. Recent experiments from our laboratory involving direct measurements of regional sympathetic nerve activity have provided further evidence that insulin acts in the central nervous system. For example, administration of insulin into the third cerebralventricle increased lumbar but not renal or adrenal sympathetic nerve activity in normotensive rats. Interestingly, this pattern of regional sympathetic nerve responses to central neural administration of insulin is similar to that seen with systemic administration of insulin. Further, lesions of the anteroventral third ventricle hypothalamic (AV3V) region abolished increases in sympathetic activity to systemic administration of insulin with euglycemic clamp, suggesting that AV3V-related structures are critical for insulin-induced elevations in sympathetic outflow.
Details
- Title: Subtitle
- Mechanisms of Insulin Action on Sympathetic Nerve Activity
- Creators
- Martin S Muntzel - 1Department of Psychology, and Internal Medicine, and the Cardiovascular Center, College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA, 52242Erling A Anderson - 1Department of Psychology, and Internal Medicine, and the Cardiovascular Center, College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA, 52242Alan Kim Johnson - 1Department of Psychology, and Internal Medicine, and the Cardiovascular Center, College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA, 52242Allyn L Mark - 1Department of Psychology, and Internal Medicine, and the Cardiovascular Center, College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.17(1-2), pp.39-50
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641969509087053
- PMID
- 7735284
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1995
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984213411902771
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