Journal article
Mechanisms of Protection of the Blood-Brain Barrier During Acute Hypertension in Chronically Hypertensive Rats
Hypertension (Dallas, Tex. 1979), Vol.9(6, Part 2 Suppl III), pp.III-101-III-105
06/1987
DOI: 10.1161/01.HYP.9.6_Pt_2.III101
PMID: 3596775
Abstract
Spontaneously hypertensive rats are less susceptible than normotensive rats to disruption of the blood-brain barrier during acute hypertension. The purpose of this study was to examine mechanisms that protect the blood-brain barrier from disruption in chronically hypertensive rats during acute hypertension. Normotensive Wistar-Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) were studied using intravital fluorescent microscopy and fluoresceinlabeled dextran. Disruption of the blood-brain barrier was characterized by the appearance of micro vascular leaky sites and quantitated by the clearance of fluorescein-labeled dextran. We measured pressure (servo null) in pial arterioles and venules 40 to 60 jam in diameter. In WKY, acute, phenylephrine-induced hypertension increased pial arteriolar pressure by 47 ± 7 mm Hg (mean ± SE) and pial venous pressure by 20 ± 2 mm Hg. Leaky sites increased from 0 to 28 ± 2. In SHRSP, acute hypertension increased pial arteriolar pressure 44 ± 8 mm Hg, but pial venous pressure increased only 6 ± 1 mm Hg and leaky sites increased from 0 to only 6 ± 1. All leaky sites were venular. In another group of WKY and SHRSP, we increased pial venous pressure passively with a neck cuff. In WKY, venous pressure increased by 22 ± 2 mm Hg, and leaky sites increased from 0 to 23 ± 2. In SHRSP, venous pressure increased by 19 ± 1 mm Hg, and leaky sites increased from 0 to 24 ± 2. Thus, when venous pressure is increased to the same level in WKY and SHRSP, disruption of the blood-brain barrier is similar. We conclude that 1) protection of the blood-brain barrier during acute hypertension in SHRSP is related to attenuation of increases in pial venous pressure, not pial arteriolar pressure, and 2) the blood-brain barrier in venules of SHRSP probably is not inherently resistant to disruption.
Details
- Title: Subtitle
- Mechanisms of Protection of the Blood-Brain Barrier During Acute Hypertension in Chronically Hypertensive Rats
- Creators
- WILLIAM MAYHAN - Department of Internal Medicine, Veterans Administration Medical Center and Cardiovascular Center, University of Iowa College of Medicine, Iowa City, IowaFRANK FARACIDONALD HEISTAD
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.9(6, Part 2 Suppl III), pp.III-101-III-105
- DOI
- 10.1161/01.HYP.9.6_Pt_2.III101
- PMID
- 3596775
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 06/1987
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040244302771
Metrics
15 Record Views