Journal article
Mechanisms of TNF receptor‐associated factor (TRAF) regulation in B lymphocytes
Journal of leukocyte biology, Vol.72(1), pp.19-23
07/2002
DOI: 10.1189/jlb.72.1.19
PMID: 12101258
Abstract
A key component of signaling by members of the tumor necrosis factor receptor (TNF‐R) family is interaction with the cytoplasmic adapter proteins known as TRAFs. Several proteins encoded by microbes also interact with TRAFs. A notable example is the CD40 receptor, expressed on antigen presenting cells and providing key activation signals in T cell‐dependent B cell activation. CD40 signals to B cells are mimicked by a constitutively active viral protein produced by the Epstein‐Barr virus. For each of these receptors, multiple mechanisms of TRAF regulation contribute to signal transduction and the ultimate effect on the B cell. Recent findings concerning these regulatory mechanisms are summarized in this overview.
Details
- Title: Subtitle
- Mechanisms of TNF receptor‐associated factor (TRAF) regulation in B lymphocytes
- Creators
- Gail A BishopBruce S HostagerKevin D Brown
- Resource Type
- Journal article
- Publication Details
- Journal of leukocyte biology, Vol.72(1), pp.19-23
- DOI
- 10.1189/jlb.72.1.19
- PMID
- 12101258
- NLM abbreviation
- J Leukoc Biol
- ISSN
- 0741-5400
- eISSN
- 1938-3673
- Number of pages
- 5
- Language
- English
- Date published
- 07/2002
- Academic Unit
- Microbiology and Immunology; President
- Record Identifier
- 9984002380902771
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