Journal article
Mechanisms of Tumor Growth and Metastasis in Head and Neck Squamous Cell Carcinoma
Current treatment options in oncology, Vol.8(3), pp.227-238
06/01/2007
DOI: 10.1007/s11864-007-0032-2
PMID: 17712533
Abstract
The formation and progression of head and neck squamous cell carcinoma (HNSCC) is multisystemic and involves the immune system, vascularization, and dissemination. Immune involvement includes the subversion of anti-tumor defenses. Vascularization involves both angiogenesis and vasculogenesis. Dissemination involves local tumor invasion as well as distant metastasis through processes including angiogenesis and lymphangiogenesis. Current studies in the dysregulation of various processes, including genetic stability, angiogenesis, lymphangiogenesis, immune regulation, and immune function, are opening opportunities for the development of targeted tumor therapies. The interrelationship of these processes in HNSCC development will be explored in this review.[PUBLICATION ABSTRACT]
Details
- Title: Subtitle
- Mechanisms of Tumor Growth and Metastasis in Head and Neck Squamous Cell Carcinoma
- Creators
- Jarrett Walsh - Ralph H. Johnson VA Medical CenterDeanne LathersAngela Chi - Medical University of South CarolinaM GillespieTerry Day - Medical University of South CarolinaM Young
- Resource Type
- Journal article
- Publication Details
- Current treatment options in oncology, Vol.8(3), pp.227-238
- Publisher
- Springer Nature B.V
- DOI
- 10.1007/s11864-007-0032-2
- PMID
- 17712533
- ISSN
- 1527-2729
- eISSN
- 1534-6277
- Language
- English
- Date published
- 06/01/2007
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984311444502771
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