Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ

Jeffrey P Coble; Justin L Grobe; Alan Kim Johnson; Curt D Sigmund

doi:10.1152/ajpregu.00486.2014

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Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ

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Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ

Jeffrey P Coble, Justin L Grobe, Alan Kim Johnson and Curt D Sigmund

American journal of physiology. Regulatory, integrative and comparative physiology, Vol.308(4), pp.R238-R249

02/15/2015

DOI: 10.1152/ajpregu.00486.2014

PMCID: PMC4347751

PMID: 25519738

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Abstract

It is critical for cells to maintain a homeostatic balance of water and electrolytes because disturbances can disrupt cellular function, which can lead to profound effects on the physiology of an organism. Dehydration can be classified as either intra- or extracellular, and different mechanisms have developed to restore homeostasis in response to each. Whereas the renin-angiotensin system (RAS) is important for restoring homeostasis after dehydration, the pathways mediating the responses to intra- and extracellular dehydration may differ. Thirst responses mediated through the angiotensin type 1 receptor (AT1R) and angiotensin type 2 receptors (AT2R) respond to extracellular dehydration and intracellular dehydration, respectively. Intracellular signaling factors, such as protein kinase C (PKC), reactive oxygen species (ROS), and the mitogen-activated protein (MAP) kinase pathway, mediate the effects of central angiotensin II (ANG II). Experimental evidence also demonstrates the importance of the subfornical organ (SFO) in mediating some of the fluid intake effects of central ANG II. The purpose of this review is to highlight the importance of the SFO in mediating fluid intake responses to dehydration and ANG II.

Blood Pressure

Receptors, Angiotensin - metabolism

Angiotensin II - metabolism

Signal Transduction

Humans

Drinking

Animals

Renin-Angiotensin System

Subfornical Organ - physiopathology

Dehydration - physiopathology

Water-Electrolyte Balance

Dehydration - metabolism

Subfornical Organ - metabolism

Details

Title: Subtitle: Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ
Creators: Jeffrey P Coble - Department of Pharmacology
Justin L Grobe - Department of Pharmacology, Center for Hypertension Research, Roy J. and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa
Alan Kim Johnson - Department of Pharmacology, Department of Psychology
Curt D Sigmund - Department of Pharmacology, Center for Hypertension Research, Roy J. and Lucille Carver College of Medicine, University of Iowa, Iowa City, Iowa curt-sigmund@uiowa.edu
Resource Type: Journal article
Publication Details: American journal of physiology. Regulatory, integrative and comparative physiology, Vol.308(4), pp.R238-R249
DOI: 10.1152/ajpregu.00486.2014
PMID: 25519738
PMCID: PMC4347751
NLM abbreviation: Am J Physiol Regul Integr Comp Physiol
ISSN: 0363-6119
eISSN: 1522-1490
Publisher: American Physiological Society; United States
Grant note: HL-062984 / NHLBI NIH HHS HL-084207 / NHLBI NIH HHS HL-048058 / NHLBI NIH HHS HL-014388 / NHLBI NIH HHS AI-04586 / NIAID NIH HHS HL-061446 / NHLBI NIH HHS T32 GM007337 / NIGMS NIH HHS P01 HL014388 / NHLBI NIH HHS HL-098207 / NHLBI NIH HHS HL-098276 / NHLBI NIH HHS P01 HL084207 / NHLBI NIH HHS
Language: English
Date published: 02/15/2015
Academic Unit: Molecular Physiology and Biophysics; Psychological and Brain Sciences; Neuroscience and Pharmacology; Health, Sport, and Human Physiology
Record Identifier: 9984002303702771

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