Journal article
Mechanisms of ischemic stroke secondary to large artery atherosclerotic disease
Neuroimaging clinics of North America, Vol.17(3), pp.303-311
08/2007
DOI: 10.1016/j.nic.2007.03.001
PMID: 17826633
Abstract
Atherosclerotic occlusive disease of the cervical and intracranial arteries leads to ischemic stroke through two separate, but interrelated, mechanisms: local thrombosis or embolism from atherosclerotic plaque, and hemodynamic failure (low flow). In this article, the author discusses the evidence linking these two mechanisms with cerebral ischemia, and the evidence for the synergistic effects of thromboembolism and impaired hemodynamics. An understanding of these two mechanisms is important because these mechanisms provide the rationale for revascularization for patients who have atherosclerotic stenosis or occlusion. In addition, the biologic imaging of atherosclerotic plaques and hemodynamic assessment eventually will play an important role in stratifying patient risk and guiding physiologically based patient selection for intervention.
Details
- Title: Subtitle
- Mechanisms of ischemic stroke secondary to large artery atherosclerotic disease
- Creators
- Colin P Derdeyn - Washington University School of Medicine, Mallinckrodt Institute of Radiology, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA. derdeync@wustl.edu
- Resource Type
- Journal article
- Publication Details
- Neuroimaging clinics of North America, Vol.17(3), pp.303-311
- Publisher
- United States
- DOI
- 10.1016/j.nic.2007.03.001
- PMID
- 17826633
- ISSN
- 1052-5149
- eISSN
- 1557-9867
- Grant note
- R01 NS51631 / NINDS NIH HHS K08 NS02029 / NINDS NIH HHS
- Language
- English
- Date published
- 08/2007
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984020656402771
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