Journal article
Mechanisms of leucocyte sodium influx in essential hypertension
Clinical science (1979), Vol.75(5), pp.521-526
11/01/1988
DOI: 10.1042/cs0750521
PMID: 3254765
Abstract
1. Leucocyte Na+ influx in media containing 10 mmol/l Na+ was studied directly using a triple-isotope method for measuring initial 22Na uptake rates in 20 normal and 18 untreated hypertensive subjects. The effects of 1 mmol/l amiloride (a Na+-H+-antiport inhibitor) and 0.1 mmol/l bumetanide (a Na+, K+, Cl−-symport inhibitor) were also examined. 2. The total, amiloride-sensitive and bumetanide-sensitive influx rates were raised in hypertensive compared with normotensive subjects [median (range): total 0.63 (0.25–1.82) vs 0.40 (0.09–0.65) mmol min−1 l−1, P < 0.002; amiloride-sensitive 0.43 (0.18–1.56) vs 0.26 (0.04–0.48) mmol min−1 l−1, P < 0.002; bumetanide-sensitive 0.12 (−0.03 to 0.83) vs 0.02 (−0.25 to 0.21) mmol min−1 l−1, P < 0.005]. 3. We conclude that hypertensive patients have a raised leucocyte total Na+ influx when measured in media containing 10 mmol/l Na+ and that this is contributed mainly by amiloride-sensitive and bumetanide-sensitive Na+ influx mechanisms.
Details
- Title: Subtitle
- Mechanisms of leucocyte sodium influx in essential hypertension
- Creators
- L. L Ng - Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.KM Harker - Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.KE. D Abel - Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, and Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, U.K
- Resource Type
- Journal article
- Publication Details
- Clinical science (1979), Vol.75(5), pp.521-526
- DOI
- 10.1042/cs0750521
- PMID
- 3254765
- ISSN
- 0143-5221
- eISSN
- 1470-8736
- Language
- English
- Date published
- 11/01/1988
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984024511502771
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